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首页> 外文期刊>Veterinary Parasitology >Assessment of the effective dose of an experimental intramuscular formulation against immature and adult Fasciola hepatica in sheep
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Assessment of the effective dose of an experimental intramuscular formulation against immature and adult Fasciola hepatica in sheep

机译：评估绵羊未成熟和成人粘性肝病实验肌肉内制剂的有效剂量

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The effective dose of an injectable prodrug, named compound alpha prodrug, against immature and adult Fasciola hepatica in experimentally infected sheep was determined. In a first experiment, 30 sheep were infected with Fasciola hepatica on day 0 and 50. After microscopic detection of faecal eggs on day 80, groups (n = 6) 1 to 3 were treated with 6, 8 and 10 mg/kg of the experimental water-soluble prodrug compound alpha intramuscularly, respectively. Group 4 was treated with closantel and group 5 remained untreated. Copromicroscopical examinations were made on day 0, 80 and 108. On day 110, trematodes were collected from the bile ducts. Fasciolicide efficacy was assessed as a percentage of fluke-egg and adult-fluke reduction. Fluke length was also recorded. In a second experiment aimed to assess the fasciolicide activity of compound alpha prodrug against four-week-old flukes, 12 sheep were infected on day 0 and allocated into two groups (n = 6). On day 50 post infection, group A was treated with the experimental water-soluble prodrug compound alpha at 6 mg/kg/IM and B remained untreated. Fasciolicide activity was assessed on day 80 after collection, microscopic observation and measurement of flukes present in the parenchyma for immature stages and on day 108 for adults. Egg output decreased 91.2, 96.0, 98.8 and 94.9% for groups 1, 2, 3 and 4, respectively. Compound alpha prodrug cleared 97.6%, 98.51% and 100% of adult stages in a dose-dependent manner. Closantel killed 81.95% flukes. Regarding the second experiment, 81.2% efficacy was achieved. Immature flukes were significantly smaller in the treated group. It is concluded that the intramuscular application of compound alpha prodrug exerted fasciolicide efficacy against adults of Fasciola hepatica.
机译：测定了在实验感染绵羊中的可注射前药，名为复合α前药的可注射前药的有效剂量。在第一次实验中，在第0天和50天感染30羊。在第80天微观检测粪便卵的微观检测后，用6,8和10mg / kg处理群（n = 6）1至3实验水溶性前药化合物分别肌肉内α-肌肉内。第4组被封定箱和第5组治疗，残留不治疗。在第0天，80和108日制造共同的考试。在第110天，从胆管中收集颤斑。将裂解效果评估为氟克蛋和成人 - 荧光减少的百分比。还记录了侥幸长度。在第二个实验中，旨在评估复合α前药的FascioLicide活性，对四周患者的群体，12羊在第0天感染并分配成两组（n = 6）。在第50天后感染后，将A组用在6mg / kg / Im的实验水溶性前药复合α处理，B残留未经处理。在收集后80天评估粉碎机活性，微观观察和在疗法中存在的群体进行未成复阶段和成人第108天。蛋产量分别减少91.2,96.0,98.8和94.9％，分别为1,2,3和4组。化合物α前药以剂量依赖性方式清除97.6％，98.51％和100％的成人阶段。 Closantel造成81.95％的群体。关于第二种实验，实现了81.2％的疗效。治疗组中未成熟的氟克斯显着较小。结论是，复合α前药的肌内应用施用迷离血糖素肝脏成虫的效果。

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