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首页> 外文期刊>Biotechnology Progress >Optimal Fed Batch Experiment Design for Estimation of Monod Kinetics of Azospirillum brasilense:From Theory to Practice
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Optimal Fed Batch Experiment Design for Estimation of Monod Kinetics of Azospirillum brasilense:From Theory to Practice

机译：估计巴西偶氮螺旋菌单链动力学的最佳分批实验设计：从理论到实践

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摘要

In this paper the problem of reliable and accurate parameter estimation for unstructured models is considered.It is illustrated how a theoretically optimal design can be successfully translated into a practically feasible,robust,and informative experiment.The well-known parameter estimation problem of Monod kinetic parameters is used as a vehicle to illustrate our approach.As known for a long time,noisy batch measurements do not allow for unique and accurate estimation of the kinetic parameters of the Monod model.Techniques of optimal experiment design are,therefore,exploited to design informative experiments and to improve the parameter estimation accuracy.During the design process,practical feasibility has to be kept in mind.The designed experiments are easy to implement in practice and do not require additional monitoring equipment.Both design and experimental validation of informative fed batch experiments are illustrated with a case study,namely,the growth of the nitrogen-fixing bacteria Azospirillum brasilense.
机译：本文考虑了非结构化模型参数可靠，准确的估计问题。说明了如何将理论上最优的设计成功地转化为实用，鲁棒和有益的实验。Monod动力学的著名参数估计问题参数用作说明我们方法的工具。众所周知，长期以来，嘈杂的批处理测量无法对Monod模型的动力学参数进行唯一而准确的估算。因此，人们开始探索设计最佳实验的技术在设计过程中，必须牢记实用性。设计的实验在实践中易于实现，不需要额外的监控设备。信息性补料批次的设计和实验验证通过案例研究说明了固氮b的生长巴西阿斯螺旋菌。

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