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首页> 外文期刊>The International journal of oral & maxillofacial implants >MMP-13 Polymorphism as a Risk Factor in Implant Loss
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MMP-13 Polymorphism as a Risk Factor in Implant Loss

机译：MMP-13多态性作为植入物损失的危险因素

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Purpose: To investigate whether MMP-13 g.-77 A > G (rs2252070) gene polymorphism is associated with early implant loss. Materials and Methods: Two hundred nonsmoking volunteers in good oral health, > 18 years of age, and found to be periodontally healthy by clinical examination were matched by age, sex, and implant position and separated into two groups: control group (100 patients with one or more healthy implants for a minimum of 1 year) and test group (100 patients who had suffered early implant loss, considered when implants presented mobility and/or pain before or during abutment connection, requiring their removal). Genomic DNA from saliva was genotyped by PCR-RFLP. Statistical analysis of the results was done using Mann-Whitney U and chi-square tests, with a significance level of 5%. Results: A significant difference in the presence of the different alleles and genotype was found between groups for the MMP-13 g.-77 A > G (rs2252010) gene polymorphism (P = .0161, OR 95% = 0.51 [0.31 to 0.89]; P = .001, OR 95% = 0.44 [0.25 to 0.18]). The A allele increased susceptibility to early implant loss and appeared to be a genetic risk factor. Conclusion: The findings suggest that MMP-13 g.-77 A > G (rs2252010) polymorphism may contribute to early implant loss.
机译：目的：探讨MMP-13 G.-77 A> G（RS2252070）基因多态性是否与早期植入物损失有关。材料和方法：两百个非营造志愿者良好的口腔健康，> 18岁，发现临床检查的牙周健康均符合年龄，性别和植入职位，分为两组：对照组（100名患者一个或多个健康的植入物至少1年）和试验组（100名患有早期植入物损失的患者，当植入物在邻接联系之前或期间植入物介绍，需要其去除）。来自唾液的基因组DNA由PCR-RFLP进行基因分型。使用Mann-Whitney U和Chi-Square试验进行结果的统计分析，其显着性水平为5％。结果：在MMP-13G-77a> G（RS2252010）基因多态性（P = .0161，或95％= 0.51 [0.31至0.89）之间存在不同等位基因和基因型存在的显着差异]; p = .001，或95％= 0.44 [0.25至0.18]）。 A等位基因增加了对早期植入物损失的敏感性，并且似乎是遗传危险因素。结论：调查结果表明，MMP-13 G.-77 A> G（RS2252010）多态性可能有助于早期植入物损失。

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