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首页> 外文期刊>Biotechnology Progress >A Possible Mechanism of Metabolic Regulation in Gibberella fujikuroi Using a Mixed Carbon Source of Glucose and Corn Oil Inferred from Analysis of the Kinetics Data Obtained in a Stirrer Tank Bioreactor
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A Possible Mechanism of Metabolic Regulation in Gibberella fujikuroi Using a Mixed Carbon Source of Glucose and Corn Oil Inferred from Analysis of the Kinetics Data Obtained in a Stirrer Tank Bioreactor

机译：从搅拌罐生物反应器中获得的动力学数据分析推断，使用葡萄糖和玉米油的混合碳源，可以对富士赤霉菌进行代谢调节的可能机理。

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摘要

A nonstructured model was used to study the dynamics of gibberellic acid production in a stirred tank bioreactor. Experimental data were obtained from submerged batch cultures of Gibberella fujikuroi (CDBB H-984) grown in varying ratios of glucose-corn oil as the carbon source. The nitrogen depletion effect was included in mathematical model by considering the specific kinetic constants as a linear function of the normalized nitrogen consumption rate. The kinetics of biomass growth and consumption of phosphate and nitrogen were based on the logistic model. The traditional first-order kinetic model was used to describe the specific consumption of glucose and corn oil. The nitrogen effect was solely included in the phosphate and corn oil consumption and biomass growth. The model fit was satisfactory, revealing the dependence of the kinetics with respect to the nitrogen assimilation rate. Through simulations, it was possible to make diagrams of specific growth rate and specific rate of substrate consumptions, which was a powerful tool for understanding the metabolic interactions that occurred during the various stages of fermentation process. This kinetic analysis provided the proposal of a possible mechanism of regulation on growth, substrate consumptions, and production of gibberellic acid (GA3) in G. fujikuroi.
机译：非结构化模型用于研究搅拌釜生物反应器中赤霉素生产的动力学。从以不同比例的葡萄糖-玉米油作为碳源生长的藤本赤霉菌（CDBB H-984）的水下分批培养物中获得实验数据。通过将比动力学常数视为归一化氮消耗速率的线性函数，将氮耗竭效应包括在数学模型中。生物量生长和磷，氮消耗的动力学基于逻辑模型。传统的一阶动力学模型用于描述葡萄糖和玉米油的比消耗。氮效应仅包括在磷酸盐和玉米油的消耗量以及生物量的增长中。模型拟合令人满意，揭示了动力学对氮同化率的依赖性。通过模拟，可以绘制特定生长速率和特定底物消耗速率的图表，这是了解发酵过程各个阶段发生的代谢相互作用的有力工具。这项动力学分析提出了一种可能的调控藤本菌中生长，底物消耗和赤霉素（GA3）的机制。

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