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首页> 外文期刊>Hearing Research: An International Journal >Motion of tympanic membrane in guinea pig otitis media model measured by scanning laser Doppler vibrometry
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Motion of tympanic membrane in guinea pig otitis media model measured by scanning laser Doppler vibrometry

机译：鼓膜在豚鼠中耳炎介质模型中的运动扫描激光多普勒振动测量

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摘要

Otitis media (OM) is an inflammatory or infectious disease of the middle ear. Acute otitis media (AOM) and otitis media with effusion (OME) are the two major types of OM. However, the tympanic membrane (TM) motion differences induced by AOM and OME have not been quantified in animal models in the literature. In this study, the guinea pig AOM and OME models were created by transbullar injection of Streptococcus pneumoniae type 3 and lipopolysaccharide, respectively. To explore the effects of OM on the entire TM vibration, the measurements of full-field TM motions were performed in the AOM, OME and untreated control ears by using scanning laser Doppler vibrometry (SLDV). The results showed that both AOM and OME generally reduced the displacement peak and produced the traveling-wave-like motions at relatively low frequencies. Compared with the normal ear, OME resulted in a significant change of the TM displacement mainly in the inferior portion of the TM, and AOM significantly affected the surface motion across four quadrants. The SLDV measurements provide more insight into sound-induced TM vibration in diseased ears. (C) 2016 Elsevier B.V. All rights reserved.
机译：中耳炎培养基（OM）是中耳的炎症或传染病。急性中耳炎（AOM）和具有积液（OME）的中耳炎介质是OM的两种主要类型。然而，由AOM和OME诱导的鼓膜（TM）运动差尚未在文献中的动物模型中量化。在这项研究中，豚鼠AOM和OME模型分别由肺炎链球菌型3型和脂多糖的Transbullar注射产生。为了探讨OM在整个TM振动上的影响，通过使用扫描激光多普勒振动器（SLDV）在AOM，OME和未处理的控制耳中进行全场TM运动的测量。结果表明，AOM和OME通常通常降低位移峰，并在相对低的频率下产生行驶波状运动。与正常耳朵相比，OME导致TM位移的显着变化主要在TM的下部，AOM显着影响四个象限的表面运动。 SLDV测量提供更多地洞察患病耳朵的声音引起的TM振动。 （c）2016年Elsevier B.v.保留所有权利。

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