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首页> 外文期刊>Trends in Ecology & Evolution >Evaluation of Continuous Infusion Vancomycin Administration in a Critically Ill Trauma Population
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Evaluation of Continuous Infusion Vancomycin Administration in a Critically Ill Trauma Population

机译：在批判性创伤群中连续输注万古霉素施用的评价

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摘要

Vancomycin is a first-line antibiotic for empiric treatment of gram-positive infections in the trauma intensive care unit. When dosed intermittently, difficulties arise from trough collection and drug monitoring. The objective of this study was to evaluate time to goal vancomycin levels comparing a continuous infusion protocol when compared to standard intermittent infusion dosing. This was a retrospective cohort of patients admitted to the trauma intensive care unit between July 2011 and July 2015 receiving vancomycin for at least 48 hours. In this cohort of 150 patients, continuous infusion vancomycin had a decreased time to goal vancomycin level (2.5 vs 3.8 days, P <= .05) with a higher incidence of target attainment (60% vs 40%, P <= .05). This reflected in a decrease in average number of blood samples per patient (1 vs 3, P <= .05) and shorter duration of therapy (3.8 vs 6.8 days, P <= .05). Patients receiving continuous infusion vancomycin also experienced less nephrotoxicity (21% vs 43%, P <= .05). Patients in the intermittent infusion group had more missed levels and doses, with only 1 in every 3 patients receiving all intended doses on time. Vancomycin continuous infusion resulted in a decrease in time to goal therapeutic vancomycin levels, number of blood samples required, and therapy duration. Larger trials are needed to validate these outcomes in broad patient groups and to validate the clinical implication and potential cost savings of these results.
机译：万古霉素是针对创伤密集护理单元中革兰氏阳性感染的仿真治疗的一线抗生素。当间歇地提出时，谷槽收集和药物监测出现困难。本研究的目的是评估目标万古霉素水平的时间，与标准间歇输注给药相比，将连续输注方案进行比较。这是2011年7月至2015年7月在2015年7月至2015年7月期间接受过48小时的患者的回顾性队列。在该队列的150名患者中，连续输注万古霉素在目标万古霉素水平（2.5 vs 3.8天，P <= 0.05）具有较高的目标达到的发生时间（60％vs 40％，P <= .05） 。这反映在每位患者的平均血液样本数量（1 vs 3，p <= .05）的降低中反映（1 Vs 3，p <= .05）和持续时间较短（3.8 Vs 6.8天，P <= .05）。接受连续输注万古霉素的患者也经历了较少的肾毒性（21％Vs 43％，P <= .05）。间歇输注组中的患者有更多的缺失水平和剂量，每3名患者只有1例接受所有预期剂量。 Vancomycin连续输注导致目标治疗万古霉素水平的减少，所需的血液样本数和治疗持续时间。需要更大的试验来验证广泛患者组中的这些结果，并验证这些结果的临床意义和潜在的成本节约。

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