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首页> 外文期刊>Trends in Ecology & Evolution >Exercise May Ameliorate the Detrimental Side Effects of High Vitamin D Supplementation on Muscle Function in Mice
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Exercise May Ameliorate the Detrimental Side Effects of High Vitamin D Supplementation on Muscle Function in Mice

机译：运动可能会改善高维生素D补充对小鼠肌肉功能的有害副作用

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Vitamin D is commonly prescribed to normalize deficiencies and to treat osteoporosis. However, the effect vitamin D supplements have on skeletal muscle health is equivocal. Although vitamin D is known to play a role in the various processes that maintain muscle integrity and function, recent studies utilizing high bolus dose vitamin D supplementation has demonstrated an increased risk of falls. Thus, the aim of this study was to investigate the effects of high vitamin D supplementation on skeletal muscle function with and without exercise enrichment. Four-week old C57BL/10 mice (n= 48) were separated into either normal vitamin D (1500 IU/kg diet; unsupplemented) or high vitamin D (20,000 IU/kg diet; supplemented) treatment groups. Each dietary group was further separated into interventional subgroups where mice either remained sedentary or received exercise-enrichment for 8 weeks in the form of voluntary running. Following the intervention period, whole body in vivo and ex vivo contractile analysis were performed. High vitamin D supplementation decreased force production in the slow-twitch soleus muscles of sedentary mice (p< .01); however, exercise normalized this effect. Eight weeks of exercise did not improve fatigue resistance of the extensor digitorum longus (EDL) or soleus muscles in unsupplemented mice, likely due to low levels of activation in these muscles. In contrast, fatigability was improved in the EDL (p< .01) and even more so in the soleus (p< .001) in the supplemented exercise-enriched group. Our data highlights that increasing vitamin D levels above normal reduces postural muscle force as seen in the soleus. Thus, unnecessary vitamin D supplementation may contribute to the increased risk of falls observed in some studies. Interestingly, when vitamin D supplementation was combined with exercise, force production was effectively restored, and fatigue resistance improved, even in muscles lowly activated. Regular exercise may modulate the effects of vitamin D on skeletal muscle, and be recommended for individuals receiving vitamin D supplements. (c) 2020 The Authors.Journal of Bone and Mineral Researchpublished by American Society for Bone and Mineral Research.
机译：维生素D通常规定正常化缺陷并治疗骨质疏松症。然而，效果维生素D补充剂对骨骼肌健康有价值。虽然已知维生素D在维持肌肉完整性和功能的各种过程中发挥作用，但最近利用高推注剂量维生素D补充的研究表明了跌倒风险增加。因此，本研究的目的是探讨高维生素D补充对骨骼肌功能的影响，无运动富集。将4周αC57BL/ 10小鼠（n = 48）分离成正常维生素D（1500 IU / kg饮食;未填充）或高维生素D（20,000 IU / kg饮食;补充）治疗组。每组膳食组进一步分解成介入亚组，其中小鼠以自愿运行的形式保持久入或接受富集的运动8周。在干预期间，进行体内和前体内收缩分析的全身。高维生素D补充在久坐小鼠的缓慢下降肌肌中的力量下降（P <.01）;但是，运动标准化了这种效果。八周的运动并未提高未填充小鼠的延伸位数（EDL）或单次肌肉的抗疲劳性，可能由于这些肌肉中的低水平活化。相比之下，EDL（P <γ01）中的疲劳性得到改善，在补充的运动浓缩组中的单独（P <.001）中甚至更含量。我们的数据突出显示，越来越多的维生素D水平正常降低了单独所见的姿势肌肉力。因此，不必要的维生素D补充可能有助于在一些研究中观察到的下降风险增加。有趣的是，当维生素D补充与运动相结合时，迫使力产量得到有效恢复，即使在肌肉较低激活的肌肉中，疲劳抗性也会得到改善。定期锻炼可以调节维生素D对骨骼肌的影响，并推荐用于接受维生素D补充剂的个体。 （c）2020作者。美国骨骼和矿物学研究会出版的骨头和矿物学学会。

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