...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Trends in Ecology & Evolution >Effect of high-dose strong statin for preventing periprocedural ischemic complications of carotid artery stenting
【24h】

Effect of high-dose strong statin for preventing periprocedural ischemic complications of carotid artery stenting

机译：高剂量强生汀治疗颈动脉支架血管缺血性并发症的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Statin therapy has been shown to induce carotid atherosclerotic plaque regression and reduce the periprocedural ischemic complications of carotid artery stenting (CAS). This study assessed the safety and usefulness of pretreatment using a high-dose strong statin (HDSS) to reduce the periprocedural ischemic complications of CAS. We analyzed 117 carotid lesions treated by CAS that were evaluated with magnetic resonance imaging (MRI) within 48 h after the procedure. For 67 lesions, an HDSS (rosuvastatin 20 mg or atorvastatin 40 mg daily) were prescribed from at least 14 days before CAS to at least 14 days after procedure (HDSS group). Clinical and angiographic data, as well as in-hospital outcomes, of the HDSS group were retrospectively compared with 50 lesions with conventional treatment without an HDSS (non-HDSS group). There were no significant differences in the baseline clinical and procedural characteristics between the two groups. There was no side effect related to the HDSS. Stroke rates were similar between the two groups (3.0% in HDSS group vs 8.0% in non-HDSS group, p = 0.22). All were minor strokes. Compared to the non-HDSS group, the HDSS group had a lower frequency of new lesions on diffusion-weighted imaging (DWI) with MRI (25.4% vs 44.0%, p = 0.0345). New ipsilateral DWI-positive rate in the HDSS group was significantly lower than in the non-HDSS group (16.4% vs 34.0%, p = 0.0275). Nonipsilateral (contralateral or posterior circulation) DWI-positive rates were similar between the two groups (13.4% vs 20.0%, p = 0.34). Pretreatment with an HDSS might reduce the periprocedural ischemic complications of CAS.
机译：已经显示他汀类药物治疗诱导颈动脉粥样硬化斑块回归并降低颈动脉支架（CAS）的纵向缺血性并发症。本研究评估了使用高剂量强生塞（HDS）进行预处理的安全性和有用性，以减少CA的霸王性缺血性并发症。我们分析了通过在手术后48小时内用磁共振成像（MRI）评估的CAS治疗的117个颈动脉病变。对于67个病变，HDSS（罗苏伐他汀20毫克或阿托伐他汀40毫克每日）在CAS前至少14天前列为步骤（HDSS组）至少14天。回顾性与HDSS组的临床和血管造影数据以及医院的结果，与50个病变进行回顾性，常规治疗没有HDSS（非HDSS组）。两组之间的基线临床和程序特征没有显着差异。没有与HDS相关的副作用。两组之间的卒中率类似（在非HDS组中的HDSS组中的3.0％vs 8.0％，P = 0.22）。一切都是轻微的抚摸。与非HDSS组相比，HDSS组在扩散加权成像（DWI）上具有MRI的新病变的较低频率（25.4％Vs 44.0％，P = 0.0345）。 HDSS组的新的IpsilateLal DWI阳性率明显低于非HDS组（16.4％Vs 34.0％，P = 0.0275）。非倾向（对侧或后循环）DWI阳性率在两组之间相似（13.4％Vs 20.0％，P = 0.34）。 HDSS的预处理可能会降低CA的霸王性缺血性并发症。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号