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The Evolutionary Consequences of Stepwise Infection Processes

机译:逐步感染过程的进化后果

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Molecular and cellular studies reveal that the resistance of hosts to parasites and pathogens is a cascade-like process with multiple steps required to be passed for successful infection. By contrast, much of evolutionary reasoning is based on strongly simplified, one-or two-step infection processes with simple genetics or on resistance being a quantitative trait. Here we attempt a conceptual unification of these two perspectives with the aim of cross-fostering research and filling some of the gaps in our concepts of the ecology and evolution of disease. This conceptual unification has a profound impact on the way we understand the genetics and evolution of host resistance, ecological immunity, evolution of virulence, defence portfolios, and host-pathogen coevolution.
机译:分子和细胞研究表明,寄生对寄生虫和病原体的抵抗力是一种级联的方法,其含有多个步骤,需要用于成功感染。 相比之下,大部分进化推理是基于强大的简化,一步或两步的感染过程,具有简单的遗传学或抵抗是一种定量性状。 在这里,我们尝试了这两个观点的概念统一,目的是跨培养研究和填补了我们对生态和疾病演变的概念的一些差距。 这种概念统一对我们了解宿主抵抗,生态免疫力,毒力,防御组合和宿主病因共参数的遗传和演变的方式具有深远的影响。

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