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首页> 外文期刊>AJR: American Journal of Roentgenology : Including Diagnostic Radiology, Radiation Oncology, Nuclear Medicine, Ultrasonography and Related Basic Sciences >MR elastography of liver tumors: preliminary results.
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MR elastography of liver tumors: preliminary results.

机译：肝肿瘤的MR弹性成像：初步结果。

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OBJECTIVE: The purpose of this study was to evaluate the potential value of MR elastography (MRE) in the characterization of solid liver tumors. MATERIALS AND METHODS: Forty-four liver tumors (14 metastatic lesions, 12 hepatocellular carcinomas, nine hemangiomas, five cholangiocarcinomas, three cases of focal nodular hyperplasia, and one hepatic adenoma) were evaluated with MRE. MRE was performed with a 1.5-T system with a modified phase-contrast gradient-echo sequence to collect axial wave images sensitized along the through-plane motion direction. The tumors were identified on T2- and T1-weighted and gadolinium-enhanced T1-weighted images, and the MRE images were obtained through the tumor. A stiffness map (elastogram) was generated in an automated process consisting of an inversion algorithm. The mean shear stiffness of the tumor was calculated with a manually specified region of interest over the tumor in the stiffness map. The stiffness value of tumor-free hepatic parenchyma was calculated. Statistical analysis was performed on the stiffness values for differentiation of normal liver, fibrotic liver, benign tumors, and malignant tumors. RESULTS: Malignant liver tumors had significantly greater mean shear stiffness than benign tumors (10.1 kPa vs 2.7 kPa, p < 0.001), fibrotic liver (10.1 kPa vs 5.9 kPa, p < 0.001), and normal liver (10.1 kPa vs 2.3 kPa, p < 0.001). Fibrotic livers had stiffness values overlapping both the benign and the malignant tumors. A cutoff value of 5 kPa accurately differentiated malignant tumors from benign tumors and normal liver parenchyma in this preliminary investigation. CONCLUSION: MR elastography is a promising noninvasive technique for assessing solid liver tumors. Use of MRE may lead to new quantitative tissue characterization parameters for differentiating benign and malignant liver tumors.
机译：目的：本研究的目的是评估磁共振弹性成像（MRE）在实体肝肿瘤表征中的潜在价值。材料与方法：用MRE评估了44例肝肿瘤（14例转移灶，12例肝细胞癌，9例血管瘤，5例胆管癌，3例局灶性结节性增生和1例肝腺瘤）。用1.5-T系统进行MRE，该系统具有改进的相衬梯度回波序列，以收集沿整个平面运动方向敏感的轴向波图像。在T2和T1加权以及and增强的T1加权图像上鉴定出肿瘤，并通过肿瘤获得MRE图像。刚度图（弹性图）是在由反演算法组成的自动化过程中生成的。使用在硬度图中手动指定的感兴趣区域来计算肿瘤的平均剪切刚度。计算无肿瘤肝实质的刚度值。对用于区分正常肝，纤维化肝，良性肿瘤和恶性肿瘤的刚度值进行统计分析。结果：恶性肝肿瘤的平均剪切刚度明显高于良性肿瘤（10.1 kPa对2.7 kPa，p <0.001），纤维化肝（10.1 kPa对5.9 kPa，p <0.001）和正常肝（10.1 kPa对2.3 kPa， p <0.001）。肝纤维化的硬度值与良性和恶性肿瘤均重叠。在该初步研究中，临界值为5 kPa可以准确地区分恶性肿瘤与良性肿瘤和正常肝实质。结论：MR弹性成像是一种有前途的无创技术，用于评估实体肝肿瘤。 MRE的使用可能会导致新的定量组织表征参数，以区分良性和恶性肝肿瘤。

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