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首页> 外文期刊>Biotechnology Progress >Exploring Cellular Adhesion and Differentiation in a Micro-/Nano-Hybrid Polymer Scaffold
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Exploring Cellular Adhesion and Differentiation in a Micro-/Nano-Hybrid Polymer Scaffold

机译：探索微/纳米杂化聚合物支架中的细胞粘附和分化。

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Polymer scaffolds play an important role in three dimensional (3-D) cell culture and tissue engineering. To best mimic the archiecture of natural extracellular matrix (ECM), a nano-fibrous and micro-porous combined (NFMP) scaffold was fabricated by combining phase separation and particulate leaching techniques. The NFMP scaffold possesses architectural features at two levels, including the micro-scale pores and nano-scale fibers. To evaluate the advantages of microlnano combination, control scaffolds with only micro-pores or nano-fibers were fabricated. Cell grown in NFMP and control scaffolds were characterized with respect to morphology, proliferation rate, diffentiation and adhesion. The NFMP scaffold combined the advantages of micro- and nano-scale structures. The NFMP scaffold nano-fibers promoted neural differentiation and induced "3-D matrix adhesion", while the NFMP scaffold micro-pores facilitated cell infiltration. This study represents a systematic comparison of cellular activities on micro-only, nano-only and microlnano combined scaffolds, and demonstrates the unique advantages of the later.
机译：聚合物支架在三维（3-D）细胞培养和组织工程中起着重要作用。为了更好地模仿天然细胞外基质（ECM）的架构，通过相分离和颗粒浸出技术的组合，制造了纳米纤维和微孔联合（NFMP）支架。 NFMP支架在两个层次上具有建筑特征，包括微尺度的孔和纳米尺度的纤维。为了评估微纳米组合的优势，制造了仅具有微孔或纳米纤维的对照支架。在形态，增殖率，分化和粘附方面表征了在NFMP和对照支架中生长的细胞。 NFMP支架结合了微米级和纳米级结构的优势。 NFMP支架纳米纤维促进神经分化并诱导“ 3-D基质粘附”，而NFMP支架微孔则促进细胞浸润。这项研究代表了对仅微米，仅纳米和微米纳米复合支架的细胞活性的系统比较，并证明了后者的独特优势。

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