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首页> 外文期刊>Human vaccines & immunotherapeutics. >Fifteen years of epidemiologic, virologic and syndromic influenza surveillance: A focus on type B virus and the effects of vaccine mismatch in Liguria region, Italy
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Fifteen years of epidemiologic, virologic and syndromic influenza surveillance: A focus on type B virus and the effects of vaccine mismatch in Liguria region, Italy

机译：十五年的流行病学，病毒学和综合征流感监测：专注于B型病毒和疫苗不匹配在意大利利古里亚地区的影响

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摘要

In order to estimate the burden of influenza and to describe the genetic evolutionary pattern and antigenic variability of type B viral strains, data deriving from 3 surveillance systems active in Liguria region, Northern Italy, were described. Since the re-emergence of the Victoria lineage in 2001, the clinical-epidemiological and syndromic surveillances demonstrated the heavy burden of influenza like illness (ILI) syndrome. Focusing on type B influenza virus, it predominated or played a relevant epidemic role in the 50% of the evaluated influenza seasons. Furthermore, the virologic surveillance demonstrated the frequent co-circulation of both lineages an heterogeneous circulation of different influenza B strains, determining a partial or complete mismatch in at least 6 influenza seasons. The undemonstrated cross-reactivity between lineages and the unpredictability of predominant lineage arose the scientific debate about the opportunity to include the quadrivalent influenza vaccine among the preventive tools to improve the protection against type B viruses. The integration of different surveillance systems highly contribute to estimate the poorly evaluated burden of type B influenza virus and help to find variants to include in the vaccine formulation.
机译：为了估算流感的负担并描述B型病毒菌株的遗传进化模式和抗原变异性，描述了来自北部意大利北部的Liguria地区活性的3种监测系统的数据。自2001年的维多利亚血统重新出现以来，临床流行病学和综合征监测表现出疾病（ILI）综合征的沉重负担。专注于B型流感病毒，它主要在评估的流感季节中的50％占主导地位或发挥了相关的疫情作用。此外，病毒学监测证明了两个谱系对不同流感B株的异质循环的频繁循环，确定至少6个流感季节的部分或完全失配。谱系之间的巨大交叉反应和主要血统的不可预测性导致科学辩论有关在预防工具中包括四肢甲型流感疫苗的机会，以改善B型病毒的保护。不同监视系统的整合高度有助于估计B型流感病毒的差价差，并有助于发现在疫苗配方中包括包括在疫苗制剂中的变体。

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