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首页> 外文期刊>Human vaccines & immunotherapeutics. >Influenza vaccination during pregnancy for prevention of influenza confirmed illness in the infants: A systematic review and meta-analysis
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Influenza vaccination during pregnancy for prevention of influenza confirmed illness in the infants: A systematic review and meta-analysis

机译：妊娠期患者预防流感的流感疫苗接种婴幼儿疾病：系统审查和荟萃分析

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摘要

Infants younger than 6months of age are at particular risk for serious illness from influenza infection. Currently available influenza vaccines are, however, not licensed for use in infants <6months old. Influenza vaccination during pregnancy elicits robust antibody responses in the women that will protect the infants against influenza infection during the first few months of life. We aimed to determine the impact of influenza vaccination during pregnancy to prevent laboratory-confirmed influenza infection and influenza-associated hospitalisations in infants <6months old.An electronic search identified all studies assessing the proposed outcomes in infants after administration of influenza vaccine during pregnancy. Two meta-analyses were performed accordingly to studies restricting the evaluation to influenza-associated hospitalisations or not.Four randomized control trials and 3 observational studies reported on the prevention of laboratory-confirmed influenza infection in infants <6months old. Maternal influenza vaccination was associated with a 48% [95% confidence interval (CI): 33 to 59] reduced risk of infants having laboratory-confirmed influenza infection. Four observational studies reported on the prevention of hospitalizations associated with laboratory-confirmed influenza infection and the pool estimate was 72% (95%CI: 39% to 87%).Receipt of influenza vaccine during pregnancy was associated with decreased risk of laboratory-confirmed influenza infection in the infants.
机译：婴儿比6个月的年龄小于流感感染严重疾病的风险。然而，目前可用的流感疫苗不受婴儿使用的许可<6个月。妊娠期间的流感疫苗接种引起植物中的肥胖抗体反应，这些反应将在寿命的前几个月内保护婴儿免受流感感染的影响。我们旨在确定妊娠期流感疫苗接种的影响，以防止婴儿的实验室证实的流感感染和流感相关住院治疗。电子搜索确定了在妊娠期间患有流感疫苗后婴儿的拟议结果的所有研究。相应地进行两次荟萃分析，以限制对流感相关住院治疗的评价或不进行评估。在婴幼儿<6个月的旧约中预防实验室确认的流感感染和3项观测研究报告。母体流感疫苗接种与48％有关[95％置信区间（CI）：33至59]降低了实验室证实流感感染的婴儿的风险。关于预防实验室型流感感染的住院治疗和池估计的四项观察研究是72％（95％CI：39％至87％）。妊娠期间的流感疫苗与实验室确认风险降低有关婴儿流感感染。

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