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首页> 外文期刊>Human Pathology >Is immunohistochemical staining for beta-catenin the definitive pathological diagnostic tool for desmoid-type fibromatosis? A multi-institutional study
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Is immunohistochemical staining for beta-catenin the definitive pathological diagnostic tool for desmoid-type fibromatosis? A multi-institutional study

机译：用于β-catenin的免疫组织化学染色，用于DED系式纤维瘤病的最终病理诊断工具？ 一个多机构研究

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Immunohistochemical staining with anti-beta-catenin antibody has been applied as a diagnostic tool for desmoid-type fibromatoses (DFs). In recent years, specific gene mutation (CTNNB1) analysis has also been reported to be useful for diagnosis of DF; however, the association between CTNNB1 mutation status and immunohistochemical staining pattern of beta-catenin is rarely reported. The purposes of this study are to clarify the relationship of the staining pattern of beta-catenin with the CTNNB1 mutation status and various clinical variables, and to investigate the significance of immunohistochemical staining of beta-catenin in cases diagnosed as DF. Between 1997 and 2017, 104 cases diagnosed as DF from 6 institutions in Japan were enrolled in this study: Nagoya University, National Cancer Center Hospital, Niigata University, Okayama University, Kyushu University, and Cancer Institute Hospital. For all cases, immunohistochemical staining of beta-catenin and gene mutation analysis of CTNNB1 were performed. Of 104 cases, 87 (84%) showed nuclear staining of beta-catenin, and 95 (91%) showed positive staining in the cytoplasm. The proportion of cases showing strong nuclear staining of beta-catenin was significantly higher in the cases with S45F than in those with T41A or wild type. The proportion of cases stained strongly in the cytoplasm rather than in the nucleus was significantly higher in the group of T41A than that of S45F or wild type. Among 17 cases in which nuclear immunostaining was absent, CTNNB1 mutation was observed in 5 cases (29.4%). There were unignorable cases of DF with negative beta-catenin immunostaining despite a definitive clinical and pathological diagnosis of DF and/or positive CTNNB1 mutation. (C) 2018 Elsevier Inc. All rights reserved.
机译：用抗β-连环素抗体染色的免疫组织化学染色已被施用为用于DESMOID型纤维酰靶（DFS）的诊断工具。近年来，还据报道，特定基因突变（CTNNB1）分析对于DF的诊断有用;然而，很少报道CTNNB1突变状态和免疫组织化学染色模式的关系。该研究的目的是阐明β-连环蛋白的染色模式与CTNNB1突变状态和各种临床变量的关系，并研究β-Catenin的免疫组化染色在诊断为DF的情况下的意义。 1997年至2017年间，日本6个机构诊断为DF的104例患者入选本研究：名古屋大学，国家癌症中心医院，Niigata大学，冈山大学，九州大学和癌症学院医院。对于所有情况，进行了β-连环素的免疫组织化学染色和CTNNB1的基因突变分析。 104例，87例（84％）显示β-连环蛋白的核染色，95（91％）显示在细胞质中阳性染色。 S45F在S45F的情况下比在T41A或野生型中的情况下显着提高β-Catenin的病例的比例显着高。在T41A组中，细胞质中强烈染色而不是核的案例比例显着高于S45F或野生型。在不存在核免疫染色的17例中，在5例（29.4％）中观察到CTNNB1突变。尽管DF和/或阳性CTNNB1突变的明确临床和病理诊断，但存在具有阴性β-catenin免疫蛋白免疫染色的不可源性的DF病例。 （c）2018年Elsevier Inc.保留所有权利。

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