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首页> 外文期刊>Human and Experimental Toxicology >Decorporation potential of lansoprazole against radiothallium (Tl-201) in internally contaminated BALB/c mice and New Zealand White rabbits
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Decorporation potential of lansoprazole against radiothallium (Tl-201) in internally contaminated BALB/c mice and New Zealand White rabbits

机译：内部受污染的Balb / C小鼠和新西兰白兔的ransoparium（TL-201）的兰辛唑唑（TL-201）

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Introduction: This study examined the decorporation potential of lansoprazole (LNP) as radioactivity decorporation agent for radiothallium (Tl-201) in internally contaminated BALB/c mice and New Zealand White rabbits using radiometry and gamma scintigraphy. Methods: Animals were divided into three groups, that is, control, pretreatment-1 (1X LNP), and pretreatment-2 (2X LNP). Mice received LNP intraperitoneally, while in rabbits LNP was given through oral route 0.5 and 1.5 h before radiothallium administration, respectively. Mice and rabbits used in the experiment were administered 1.48 and 11.1 MBq radiothallium ((TlCl)-Tl-201) through intravenous and oral route, respectively. Once started as prophylactic, LNP was continued as therapeutic twice a day till the end of study period. Radiometry and gamma scintigraphy were used to monitor radiothallium retention and uptake patterns in animals. Gamma scintigraphic images of rabbits were taken at different time intervals up to 72 h and were analyzed for comparative uptake pattern of (TlCl)-Tl-201 in all the groups. Results: LNP treatment significantly increased the Tl-201 elimination over untreated control and considerably reduced the retention of Tl-201 in various tissues and organs. Decrease in radiothallium uptake up to 40% was observed in LNP-treated mice as compared to untreated control. While in rabbits, whole-body radioactivity burden at 72 h was found to be 31.24%, 26%, and 18.54% in untreated control, 9 and 18 mg/kg LNP-treated groups, respectively. Conclusion: LNP exhibited dose-dependent decorporation potential to effectively enhance the elimination of Tl-201 in mice and rabbits experimentally contaminated with (TlCl)-Tl-201.
机译：介绍：本研究检测了利斯拉唑（LNP）作为放射性肌肉（TL-201）的放射性肌肉（TL-201），使用辐射测定和伽马闪烁术中的新西兰白兔在内部受污染的BALB / C小鼠和新西兰白兔。方法：将动物分为三组，即对照，预处理-1（1X LNP）和预处理-2（2X LNP）。小鼠腹膜内接受LNP，同时在兔子中通过口服0.5和1.5小时给出，分别在辐射镓施用前给出。通过静脉内和口服途径施用实验中使用的小鼠和兔子。一旦开始作为预防性，LNP每天持续两次，直到研究期结束。辐射测定和伽马闪烁图用于监测动物中的辐射碱保留和摄取图案。兔子的伽马闪烁图像以不同的时间间隔拍摄，高达72小时，并在所有组中分析（TLCL）-T-201的比较摄取模式。结果：LNP治疗显着提高了未处理对照的TL-201消除，并显着降低了各种组织和器官TL-201的保留。与未处理的对照相比，在LNP处理的小鼠中观察到降低到40％的放射性钙质摄取降低。在兔子中，在未处理对照，9和18mg / kg的LNP治疗组中，发现72小时的全身放射性负荷分别为31.24％，26％和18.54％。结论：LNP表现出剂量依赖的装饰潜力，有效增强小鼠的TL-201消除（TLCL）-TL-201实验污染的兔子。

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