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首页> 外文期刊>Human and Experimental Toxicology >Vanillin mitigates the adverse impact of cisplatin and methotrexate on rat kidneys
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Vanillin mitigates the adverse impact of cisplatin and methotrexate on rat kidneys

机译：香草蛋白减轻了顺铂和甲氨蝶呤对大鼠肾脏的不利影响

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摘要

The present study investigated the probable protective effect of vanillin (VLN) against kidney injury induced by cisplatin (CSN) and methotrexate (MTX) in rats. The rats received a single injection of either CSN (7.5 mg/kg, i.p.) or MTX (20 mg/kg, i.p.). VLN treatment (150 mg/kg/day, i.p.) was started 1 day before administration of the nephrotoxic agents and continued for 7 days. Both CSN and MTX significantly increased serum creatinine, cystatin C, and neutrophil gelatinase-associated lipocalin and kidney tissue renal malondialdehyde, inducible nitric oxide synthase, tumor necrosis factor-, interleukin-18, nuclear factor-B p65, cytosolic cytochrome C, and caspase-3 and significantly decreased renal total antioxidant capacity and Bcl-2/Bax ratio in rats. VLN significantly ameliorated the changes of biochemical parameters induced by CSN and MTX. VLN also significantly reduced CSN- and MTX-induced histopathological injury and the expression of Fas ligand in rat kidneys. In conclusion, VLN significantly protected against CSN- and MTX-induced kidney injury in rats by inhibiting oxidative/nitrosative stress, inflammation, and apoptosis.
机译：本研究研究了香草蛋白（VLN）对大鼠顺铂（CSN）和甲氨蝶呤（MTX）诱导的肾损伤的可能保护作用。大鼠接受单一注射CSN（7.5mg / kg，i.p.）或mTx（20mg / kg，i.p）。在施用肾毒性药物之前，VLN治疗（150mg / kg /天，I.P.）在施用肾毒剂前一天开始并持续7天。 CSN和MTX均显着增加血清肌酐，胱抑素C和中性粒细胞明胶酶相关脂素和肾脏组织肾丙二醛，诱导型一氧化氮合酶，肿瘤坏死因子，白细胞介素-18，核因子-B P65，细胞溶质细胞色素C和Caspase -3，大鼠肾全抗氧化能力和Bcl-2 / Bax比显着降低。 VLN显着改善了CSN和MTX诱导的生物化学参数的变化。 VLN还显着降低了CSN和MTX诱导的组织病理学损伤和大鼠肾脏中Fas配体的表达。总之，通过抑制氧化/亚硝化应激，炎症和细胞凋亡，VLN显着免受CSN-和MTX诱导的肾脏损伤。

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