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首页> 外文期刊>Alcohol >The relationship between naloxone-induced cortisol and mu opioid receptor availability in mesolimbic structures is disrupted in alcohol dependent subjects
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The relationship between naloxone-induced cortisol and mu opioid receptor availability in mesolimbic structures is disrupted in alcohol dependent subjects

机译：在酒精依赖受试者中，纳洛酮诱导的皮质醇和中亚边缘结构中的μ阿片样物质受体可用性之间的关系被破坏

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The mu opioid receptor system is altered in alcohol dependent (AD) subjects. Cortisol responses to opioid receptor antagonists are assumed to impart information about opioid receptor activity. In the present study we examined naloxone-induced cortisol responses in 18 healthy control (HC) and 25 recently detoxified AD subjects and then correlated the cortisol response with mu opioid receptor availability across 15 brain regions using positron emission tomography (PET) and the mu opioid receptor selective ligand [11C] Carfentanil (CFN). On average the AD subjects required twice the dose of naloxone to induce a peak cortisol response compared to the HC subjects. Using the rising slope of the cortisol curve (placebo to peak) as a metric we then went on to examine the relationship between cortisol responses to naloxone and [11C]CFN BPND. There were significant negative relationships between cortisol and [11C]CFN binding potential (BPND) in multiple brain regions of HC subjects. However, cortisol responses did not correlate with [11C]CFN BPND across any brain region in AD subjects. In summary, naloxone imparts information about individual differences in mu opioid receptor availability throughout the mesolimbic system in healthy individuals. However pathways governing the relationship between naloxone-induced cortisol and mu opioid receptor availability are disrupted during early abstinence in AD subjects.
机译：在酒精依赖性（AD）受试者中，μ阿片受体系统发生了改变。假定皮质醇对阿片受体拮抗剂的反应可提供有关阿片受体活性的信息。在本研究中，我们检查了18名健康对照（HC）和25名最近解毒的AD受试者中纳洛酮诱导的皮质醇反应，然后使用正电子发射断层扫描（PET）和mu阿片类药物将皮质醇反应与15个大脑区域的mu阿片样物质受体可用性相关联受体选择性配体[11C]卡芬太尼（CFN）。与HC受试者相比，AD受试者平均需要两倍的纳洛酮剂量才能诱导皮质醇峰值应答。然后，使用皮质醇曲线的上升斜率（安慰剂至峰值）作为度量标准，我们接着研究了皮质醇对纳洛酮和[11C] CFN BPND的反应之间的关系。在HC受试者的多个脑区域中，皮质醇和[11C] CFN结合潜力（BPND）之间存在显着的负相关。但是，皮质醇反应与AD受试者中任何大脑区域的[11C] CFN BPND不相关。总之，纳洛酮提供有关健康个体整个中肢边缘系统中μ阿片样物质受体可用性的个体差异的信息。然而，在AD受试者的早期禁欲期间，控制纳洛酮诱导的皮质醇和μ阿片样物质受体可利用性之间的关系的途径被破坏。

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