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首页> 外文期刊>Alcohol >Central neuropeptide Y alters ethanol-induced sedation,but not ethanol intake, in C57BL/6 mice.
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Central neuropeptide Y alters ethanol-induced sedation,but not ethanol intake, in C57BL/6 mice.

机译：在C57BL / 6小鼠中，中枢神经肽Y改变了乙醇诱导的镇静作用，但没有改变乙醇摄入量。

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Recent evidence indicates that neuropeptide Y modulates neurobiologic responses to ethanol and ethanol consumption. Resistance to the sedative effects of ethanol, voluntary ethanol consumption, or both was found to be inversely related to neuropeptide Y levels in genetically manipulated rat and mouse models. More recently, intracerebroventricular infusion of neuropeptide Y reduced ethanol drinking in rats selectively bred for high ethanol preference, but not in low-ethanol-preferring or in outbred Wistar rats. In the current study, we determined whether intracerebroventricular infusion of neuropeptide Y would reduce voluntary ethanol consumption in high-ethanol-preferring, C57BL/6 mice. We also studied ethanol-induced sedation after intracerebroventricular infusion of neuropeptide Y. Pretreatment with doses of neuropeptide Y, ranging from 3.0 to 10.0 microg, significantly augmented ethanol-induced sedation without altering locomotor activity or plasma ethanol levels. However, neither a 5.0- nor a 10.0-microg dose of neuropeptide Y altered 2-h drinking of a 10% [volume/volume (vol./vol.)] ethanol solution. Consistent with genetic evidence, the results of current pharmacologic studies provide support that neuropeptide Y modulates ethanol-induced sedation.
机译：最近的证据表明，神经肽Y调节对乙醇和乙醇消耗的神经生物学反应。在经过基因处理的大鼠和小鼠模型中，发现对乙醇的镇静作用和/或自愿摄入乙醇的抵抗力与神经肽Y水平成反比。最近，脑室注入神经肽Y减少了为高乙醇偏好而选择性饲养的大鼠的饮酒，但在低乙醇偏好或近交Wistar大鼠中却没有。在当前的研究中，我们确定了脑室注射神经肽Y是否会减少对高乙醇偏爱的C57BL / 6小鼠的自愿乙醇消耗。我们还研究了脑室内注入神经肽Y后乙醇诱导的镇静作用。神经肽Y剂量在3.0至10.0 microg之间进行预处理，可显着增强乙醇诱导的镇静作用，而不会改变运动能力或血浆乙醇水平。然而，5.0或10.0微克剂量的神经肽Y不会改变10％[体积/体积（体积/体积）]乙醇溶液的2小时饮用量。与遗传证据一致，当前的药理研究结果为神经肽Y调节乙醇诱导的镇静作用提供了支持。

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