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首页> 外文期刊>Alcohol >Effects of concurrent access to a single concentration or multiple concentrations of ethanol on the intake of ethanol by male and female periadolescent alcohol-preferring (P) rats.
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Effects of concurrent access to a single concentration or multiple concentrations of ethanol on the intake of ethanol by male and female periadolescent alcohol-preferring (P) rats.

机译：同时使用单一浓度或多种浓度的乙醇对雄性和雌性青少年期酒精偏爱（P）大鼠摄入乙醇的影响。

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摘要

The objectives of this study were to assess the effects of access to different concentrations of ethanol and sex of the animal on ethanol consumption during periadolescence [postnatal days (PNDs) 30-60] in alcohol-preferring (P) rats. On PND 28, female and male P pups were single housed in hanging stainless steel cages with ad libitum access to water and food. Beginning on PND 30, the rats were also given access to either a single concentration [15% volume/volume (vol./vol.)] or multiple concentrations [10%, 20%, and 30% (vol./vol.)] of ethanol. Differences between sex (male vs. female) and ethanol conditions (single concentration vs. multiple concentrations), for the average amount of ethanol consumed for each week (starting on PND 33) of access, were examined. Analyses of the data for ethanol drinking revealed significant (P<.025) main effects of week and ethanol condition, as well as a significant weekxethanol condition interaction. For the first week, both male and female P pups consumed more ethanol under the multiple-ethanol-concentration condition than under the single-ethanol-concentration condition. However, across the second through fourth weeks, this pattern was seen only in female P pups. When preference for one concentration of ethanol over the other concentrations was assessed, it was found that male P pups tended to choose the 30% concentration over the 10% and 20% concentrations, whereas female P pups did not display a preference. The findings of this study corroborate previous work indicating that periadolescent P rats readily acquire high-ethanol-drinking behavior and that, similar to adult P rats, concurrent access to multiple concentrations of ethanol further enhances ethanol intake. These findings suggest to us that innate genetically influenced mechanisms promoting high ethanol intake are present at this stage of development.
机译：这项研究的目的是评估偏爱酒精的（P）大鼠在青春期[产后天数（PNDs）30-60]期间摄入不同浓度乙醇和动物性别对乙醇消耗的影响。在PND 28上，雌性和雄性P型幼犬被单独安置在悬挂的不锈钢笼中，随意取水和进食。从PND 30开始，大鼠也可以使用单一浓度[15％体积/体积（体积/体积）]或多种浓度[10％，20％和30％（体积/体积））。 ]的乙醇。检查了每周（从PND 33开始）每周平均消耗的乙醇量，检查了性别（男性与女性）和乙醇状况（单浓度与多种浓度）之间的差异。对乙醇饮酒数据的分析显示，每周和乙醇状况的显着（P <.025）主要影响，以及显着的周乙醇状况相互作用。对于第一周，雄性和雌性P幼犬在多乙醇浓度条件下比在单乙醇浓度条件下消耗更多的乙醇。但是，在第二到第四周，这种模式仅在雌性P幼犬中可见。当评估一种乙醇对其他浓度的偏爱时，发现雄性P幼犬倾向于选择30％的浓度，而不是10％和20％的浓度，而雌性P幼犬则没有偏爱。这项研究的结果证实了以前的工作，表明青春期P大鼠很容易获得高乙醇饮用行为，并且与成年P大鼠相似，同时摄入多种浓度的乙醇进一步提高了乙醇的摄入。这些发现向我们表明，在发育的这个阶段存在促进高乙醇摄入的先天遗传影响机制。

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