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首页> 外文期刊>Alcohol >Polymorphisms in the interleukin-10 gene promoter and the risk of alcoholism and alcoholic liver disease in Caucasian Spaniard men.
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Polymorphisms in the interleukin-10 gene promoter and the risk of alcoholism and alcoholic liver disease in Caucasian Spaniard men.

机译：白种西班牙男人中白细胞介素10基因启动子的多态性与酒精中毒和酒精性肝病的风险。

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Controversy surrounds the possible influence of the single nucleotide polymorphisms (SNPs) of the interleukin-10 (IL-10) gene promoter on the risk for alcoholic liver disease. Our aim was to determine whether the SNP of the IL-10 gene promoter are associated with an increased risk for alcoholism and for alcoholic liver disease in male Spaniards. The -627 C>A SNP of the IL-10 gene promoter was assessed in a cohort of 344 Caucasian Spanish men, 168 alcoholics, and 176 nonalcoholics. The alcoholic group comprised 79 individuals without liver histopathologic abnormalities and 89 patients with chronic alcoholic liver disease. The nonalcoholic group was made of 62 healthy controls and 114 patients with chronic nonalcoholic liver disease. Genotyping was performed using PCR and automatic sequencing analysis methods on white cell DNA. Genotype and allele frequencies were compared by using the chi(2) test. Overall, no differences in either genotype and allele distribution was observed when comparing the four patient categories defined (P=0.62 and P=0.33, respectively). Subset analyses showed no differences in the genotype and allele distributions between all alcoholic and all nonalcoholic subjects (P=0.55 and P=0.29, respectively). This study failed to detect significant associations of the IL-10 -627C>A SNP and alcoholism or alcoholic liver disease in a cohort of Caucasian male Spaniards.
机译：争议围绕白介素10（IL-10）基因启动子的单核苷酸多态性（SNP）对酒精性肝病风险的可能影响。我们的目的是确定男性西班牙人中IL-10基因启动子的SNP是否与酗酒和酒精性肝病的风险增加相关。在344名西班牙白人男子，168名酗酒者和176名非酗酒者的队列中评估了IL-10基因启动子的-627 C> A SNP。酒精中毒者包括79名无肝组织病理学异常的个体和89名慢性酒精中毒性肝病患者。非酒精组由62名健康对照组和114例慢性非酒精性肝病患者组成。使用PCR和自动测序分析方法对白细胞DNA进行基因分型。基因型和等位基因频率通过使用chi（2）测试进行比较。总体而言，当比较定义的四个患者类别时（分别为P = 0.62和P = 0.33），在基因型和等位基因分布上均未观察到差异。子集分析显示所有酒精受试者和所有非酒精受试者之间的基因型和等位基因分布没有差异（分别为P = 0.55和P = 0.29）。这项研究未能发现一群白人西班牙裔男性中IL-10 -627C> A SNP与酒精中毒或酒精性肝病之间存在显着相关性。

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