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首页> 外文期刊>Alcohol >Alcohol self-administration in rats: Modulation by temporal parameters related to repeated mild social defeat stress.
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Alcohol self-administration in rats: Modulation by temporal parameters related to repeated mild social defeat stress.

机译：大鼠酒精自我给药：与反复轻度社交失败压力相关的时间参数调节。

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Clinical evidence often points to stress as a cause or an antecedent to the development of drinking problems. Yet, animal models of alcohol drinking have yielded inconsistent evidence for a direct contribution of stress, and many studies have shown that stress suppresses alcohol consumption. The aim of the present study was to examine alcohol reward in animals exposed to repeated, mild social stress, and to determine whether alcohol drinking changes as a function of the temporal parameters of alcohol access relative to the stressor. Male Long-Evans rats, trained to self-administer a 6% (wt/vol) alcohol solution using a sucrose-fading procedure, were exposed to five brief (5min) episodes of contact with an aggressive male. Full contact with the resident was limited to a single episode of defeat, whereas the following four encounters occurred with the subjects behind a protective wire mesh cage. Alcohol self-administration was measured 1 week prior to stress (baseline), on each day of stress exposure, and 1 week following stress. Separate groups of animals were randomly assigned to self-administer alcohol immediately prior, immediately following, or 2h following defeat stress. Stress preferentially increased alcohol drinking on stress-exposure days, and further elevated the amount consumed 1 week following stress. Temporal parameters of alcohol access relative to the stressor were found to be important. Average alcohol consumption was greatest for animals drinking 2h postdefeat, whereas animals drinking immediately prior to or following the stressor did not show a significant increase in alcohol consumption. Results suggest that mild social defeat stress is sufficient to elicit increases in alcohol consumption in nonpreferring strains of rodents, provided alcohol access occurs at an optimal time interval after the social defeat experience.
机译：临床证据通常指出压力是导致饮酒问题的原因或先因。然而，饮酒的动物模型对于压力的直接作用产生了不一致的证据，许多研究表明，压力会抑制酒精的消耗。本研究的目的是检查遭受反复轻度社会压力的动物的酒精奖励，并确定饮酒是否根据相对于应激源的饮酒时间参数变化。雄性Long-Evans大鼠经过训练，可以使用蔗糖褪色程序自行施用6％（wt / vol）的酒精溶液，并与攻击性雄性动物进行五次短暂（5分钟）接触。与居民的充分接触仅限于一次失败，而随后的四次接触发生在被保护丝网笼后面的对象。在压力前（基线）1周，在压力暴露的每一天和压力后1周测量酒精自我给药。在失败压力之前，之后或之后2小时，将单独的动物组随机分配给自己服用酒精。压力优先增加了在压力暴露天的饮酒量，并进一步增加了压力后1周的消耗量。发现相对于应激源而言，酒精获取的时间参数很重要。灭绝后2h喝水的动物的平均酒精消耗量最大，而紧挨着应激源之前或之后饮酒的动物的酒精消耗量却没有显着增加。结果表明，只要在社交挫败经历后的最佳时间间隔内获取酒精，轻度的社交挫败压力就足以引起非优选啮齿动物品系的饮酒量增加。

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