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首页> 外文期刊>Alcohol >Cortical perfusion in alcohol-dependent individuals during short-term abstinence: relationships to resumption of hazardous drinking after treatment.
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Cortical perfusion in alcohol-dependent individuals during short-term abstinence: relationships to resumption of hazardous drinking after treatment.

机译：短期戒酒期间酒精依赖者的皮质灌注：与治疗后恢复有害饮酒的关系。

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Relapse to hazardous levels of alcohol consumption after treatment for alcohol use disorders is common. Investigation of the neurobiological correlates of resumption of hazardous drinking is necessary to clarify the mechanisms contributing to relapse. Fifty-seven treatment-seeking alcohol-dependent participants (ALC) completed arterial spin labeling perfusion MRI of the frontal and parietal gray matter (GM) at 7+/-3 days of abstinence (baseline). ALC participants were restudied after 35+/-11 days of abstinence (assessment point 2: AP2). Twenty-eight nonsmoking, light-drinking control participants (nsLD) from the community were studied with perfusion MRI. ALC participants were followed over 12 months after baseline study and were classified as abstainers (no alcohol consumption; n=19) and resumers (any alcohol consumption; n=38) at follow-up. Cross-sectional and longitudinal perfusion was compared in abstainers, resumers, and nsLD. At baseline, resumers demonstrated significantly lower frontal and parietal GM perfusion than nsLD and abstainers. Abstainers and nsLD were not different on frontal or parietal GM perfusion. No significant longitudinal perfusion changes were observed in abstainers and resumers. At AP2, resumers showed significantly lower frontal GM perfusion than nsLD and abstainers, whereas no group differences were observed for parietal GM. Abstainers and nsLD were not different on frontal GM perfusion. The significantly decreased frontal GM perfusion in resumers compared with both abstainers and nsLD across the assessment interval suggests premorbid and/or acquired neurobiological abnormalities of the frontal GM in resumers.
机译：酒精使用障碍的治疗后，通常会复发到危险的酒精消费水平。有必要对恢复危险饮酒的神经生物学相关因素进行研究，以阐明促成复发的机制。 57名寻求酒精依赖治疗的参与者（ALC）在禁欲7 +/- 3天（基线）时完成了额叶和顶叶灰质（GM）的动脉旋转标记灌注MRI。在禁欲期35 +/- 11天后对ALC参与者进行了重新评估（评估点2：AP2）。来自社区的28名非吸烟，轻度饮酒的控制参与者（nsLD）通过灌注MRI进行了研究。在基线研究后的12个月内，对ALC参与者进行了随访，并在随访中被分为戒酒者（无饮酒; n = 19）和恢复者（任何饮酒; n = 38）。比较了弃权者，恢复者和nsLD的横截面和纵向灌注。基线时，恢复者的额叶和顶叶GM灌注显着低于nsLD和放弃者。弃权药和nsLD在额叶或顶壁GM灌注方面无差异。在弃权者和恢复者中未观察到明显的纵向灌注变化。在AP2，恢复者的额叶GM灌注显着低于nsLD和弃权者，而顶壁GM没有观察到组间差异。弃权者和nsLD在额叶GM灌注方面没有差异。在整个评估期间，与弃权者和nsLD相比，恢复者的额叶GM灌注显着减少，这表明恢复者的额叶GM的病态和/或获得性神经生物学异常。

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