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Alcohol and immunology: Summary of the 2012 Alcohol and Immunology Research Interest Group (AIRIG) meeting

机译：酒精与免疫学：2012年酒精与免疫学研究兴趣小组（AIRIG）会议摘要

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摘要

On October 27, 2012, the 17th annual Alcohol and Immunology Research Interest Group (AIRIG) meeting was held at the Grand Wailea Hotel in Maui, Hawaii as a satellite meeting to the 2012 Society of Leukocyte Biology conference. This year's meeting focused on the influence of alcohol on signal transduction pathways in various disease and injury models. Three plenary sessions were held where invited speakers shared their research on alcohol-mediated alterations of cell signaling components, immune cell subsets, and inflammation. These studies suggested alcohol has a negative effect on cell signaling machinery and immune cell homeostasis, resulting in disease, disease progression, and increased mortality. Researchers also identified tissue-specific alcohol-linked elevations in markers of inflammation, including cold-shock proteins and microRNAs. Additionally, one study revealed the effects of alcohol on immune cell subsets in a model of allergic asthma.
机译：2012年10月27日，第17届年度酒精与免疫学研究兴趣小组（AIRIG）会议在夏威夷毛伊岛的大威雷亚酒店举行，作为2012年白细胞生物学学会会议的卫星会议。今年的会议重点讨论了酒精对各种疾病和伤害模型中信号转导途径的影响。举行了三场全体会议，邀请的演讲者分享了他们对酒精介导的细胞信号转导成分，免疫细胞亚群和炎症改变的研究。这些研究表明，酒精对细胞信号传导机制和免疫细胞稳态具有负面影响，导致疾病，疾病进展和死亡率增加。研究人员还确定了炎症标志物（包括冷激蛋白和microRNA）中与组织特异性的酒精相关的升高。此外，一项研究揭示了酒精对过敏性哮喘模型中免疫细胞亚群的影响。

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