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首页> 外文期刊>Magnetic resonance imaging: An International journal of basic research and clinical applications >Asymmetric Orientation Distribution Functions (AODFs) revealing intravoxel geometry in diffusion MRI
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Asymmetric Orientation Distribution Functions (AODFs) revealing intravoxel geometry in diffusion MRI

机译：不对称取向分布函数（AODFS）在扩散MRI中揭示椎间外几何形状

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摘要

Characterization of anisotropy via diffusion MRI reveals fiber crossings in a substantial portion of voxels within the white-matter (WM) regions of the human brain. A considerable number of such voxels could exhibit asymmetric features such as bends and junctions. However, widely employed reconstruction methods yield symmetric Orientation Distribution Functions (ODFs) even when the underlying geometry is asymmetric. In this paper, we employ inter-voxel directional filtering approaches through a cone model to reveal more information regarding the cytoarchitectural organization within the voxel. The cone model facilitates a sharpening of the ODFs in some directions while suppressing peaks in other directions, thus yielding an Asymmetric ODF (AODF) field. We also show that a scalar measure of AODF asymmetry can be employed to obtain new contrast within the human brain. The feasibility of the technique is demonstrated on in vivo data obtained from the MGH-USC Human Connectome Project (HCP) and Parkinson's Progression Markers Initiative (PPMI) Project database. Characterizing asymmetry in neural tissue cytoarchitecture could be important for localizing and quantitatively assessing specific neuronal pathways.
机译：通过扩散MRI对各向异性的表征揭示了人脑的白物（WM）区域内的大部分体素中的纤维交叉。相当数量的这样的体素可以表现出不对称的特征，例如弯曲和结。然而，广泛采用的重建方法即使当底层几何形状不对称时，也会产生对称取向分布函数（ODF）。在本文中，我们通过锥形模型采用体素方向滤波方法，以揭示关于体素内的细胞建筑组织的更多信息。锥形模型有助于在一些方向上倾斜ODF，同时抑制其他方向的峰，从而产生不对称的ODF（AODF）场。我们还表明，可以使用AODF不对称的标量测量来获得人脑内的新对比度。在从MGH-USC人体连接项目（HCP）和PARKINSON的进展标记倡议（PPMI）项目数据库中获得的体内数据中的可行性。神经组织细胞构质的不对称性的表征对于定位和定量评估特异性神经元途径可能是重要的。

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