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首页> 外文期刊>Magnetic resonance imaging: An International journal of basic research and clinical applications >Optimized super-selective Arterial Spin Labeling for quantitative flow territory mapping
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Optimized super-selective Arterial Spin Labeling for quantitative flow territory mapping

机译：优化的超选择性动脉旋转标签，用于定量流动局部映射

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摘要

Flow territory mapping using Arterial Spin Labeling (ASL) methods allows for deeper insights into the physiology of the brain. However, in most approaches assumptions of the labeling efficiency are used for calculation of brain perfusion which might result in inaccuracies. This becomes more important in super-selective ASL as the labeling focus could be positioned not exactly at the artery of interest. Therefore, measuring the labeling efficiency of the current scan seems important to obtain reliable results and to correct for potential errors. In this study, an optimized super-selective ASL tagging scheme is presented and the labeling efficiency is measured using quantitative phase-contrast angiography of the tagged artery and considering the volume of the supplied flow territory. The aim then is to evaluate the labeling efficiency of super-selective ASL and considering these values when shifting the labeling spot away from the artery of interest. The measured efficiency is compared to simulations performed for the optimized super-selective ASL approach. Considering the values of labeling efficiency after shifting the labeling focus, the values of cerebral blood flow still show accurate results despite the expected lower SNR up to an offset of 3 mm. Following this, to obtain accurate results for quantifying super-selective ASL perfusion images, measuring the labeling efficiency seems necessary to prevent false results.
机译：使用动脉旋转标签（ASL）方法的流动区域映射允许深入了解大脑的生理学。然而，在大多数方法中，标记效率的假设用于计算脑灌注，这可能导致不准确。这在超选择性ASL中变得更加重要，因为标记焦点不能完全在感兴趣的动脉定位。因此，测量当前扫描的标记效率似乎是重要的，以获得可靠的结果并纠正潜在的误差。在该研究中，提出了优化的超选择性ASL标记方案，并使用标记动脉的定量相位对比血管造影测量标记效率，并考虑所提供的流动区域的体积。然后，目的是评估超选择性ASL的标记效率，并考虑这些值，当将标记点远离感兴趣的动脉时。将测量的效率与针对优化的超选择性ASL方法进行比较进行比较。考虑到旋转标记对焦后标记效率的值，脑血流的值仍显示出准确的结果，尽管预期的下部SNR高达3毫米。在此之后，为了获得量化超选择性ASL灌注图像的准确结果，测量标记效率似乎是必要的，以防止错误结果。

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