Synthesis of a Ruthenium(II) Compound based on 5-(2-Pyrimidyl)-1H-tetrazole for Photodynamic Therapy

Wei Bo; Guo Meng Yue; Lu Yi Ming; Sun Peng Peng; Yang Gao Wen; Li Qiao Yun

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Synthesis of a Ruthenium(II) Compound based on 5-(2-Pyrimidyl)-1H-tetrazole for Photodynamic Therapy

机译：基于5-（2-嘧啶）-1H-四唑用于光动力治疗的钌（II）化合物的合成

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Ru-II compounds have been universally investigated due to their unique physical and chemical properties. In this paper, a new Ru-II compound based on 2,2-bipy and Hpmtz [2,2-bipy = 2,2-bipyridine, Hpmtz = 5-(2-pyrimidyl)-1H-tetrazole], namely [Ru(2,2-bipy)(2)(pmtz)][PF6].0.5H(2)O was prepared and characterized by elemental analysis, IR and single-crystal X-ray diffraction. [Ru(2,2-bipy)(2)(pmtz)][PF6].0.5H(2)O shows a mononuclear structure and forms a three-dimensional network by non-classic hydrogen bonds. The ability of generation of ROS (reactive oxygen species) makes it has a low phototoxicity IC50 (half-maximal inhibitory concentration) after Xenon lamp irradiation on Hela cells in vitro. The results demonstrate that [Ru(2,2-bipy)(2)(pmtz)][PF6].0.5H(2)O with high light toxicity and low dark toxicity may be a potential candidate for photodynamic therapy.

机译：由于其独特的物理和化学性质，Ru-II化合物已被普遍研究。本文中，基于2,2-Bipy和HPMTz的新Ru-II化合物[2,2-Bipy = 2,2-吡啶，HPMTZ = 5-（2-嘧啶基）-1H-四唑]，即[ru （2,2-Bipy）（2）（2）（PMTZ）] [PF6] .0.5H（2）o通过元素分析，IR和单晶X射线衍射来制备和表征。 [Ru（2,2-Bipy）（2）（2）（PMTZ）] [PF6] .0.5H（2）O显示单核结构，并通过非经典氢键形成三维网络。在体外，在氙灯照射后，在氙灯照射后，产生ROS（反应性氧物质）的能力使其具有低光毒性IC50（半最大抑制浓度）。结果表明，具有高光毒性和低暗毒性的[Ru（2,2-Bipy）（2）（PMTZ）]，0.0.5H（2）o可以是光动力治疗的潜在候选者。

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来源
《Zeitschrift fur Anorganische und Allgemeine Chemie》 |2018年第1期|共6页
作者
Wei Bo; Guo Meng Yue; Lu Yi Ming; Sun Peng Peng; Yang Gao Wen; Li Qiao Yun;
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Changshu Inst Technol Jiangsu Lab Adv Funct Mat Changshu 215500 Jiangsu Peoples R China;

Changshu Inst Technol Jiangsu Lab Adv Funct Mat Changshu 215500 Jiangsu Peoples R China;

Changshu Inst Technol Jiangsu Lab Adv Funct Mat Changshu 215500 Jiangsu Peoples R China;

Changshu Inst Technol Jiangsu Lab Adv Funct Mat Changshu 215500 Jiangsu Peoples R China;

Changshu Inst Technol Jiangsu Lab Adv Funct Mat Changshu 215500 Jiangsu Peoples R China;

Changshu Inst Technol Jiangsu Lab Adv Funct Mat Changshu 215500 Jiangsu Peoples R China;

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正文语种 eng
中图分类化学;
关键词
5-(2-Pyrimidyl)-1H-tetrazole; Ruthenium; Hela cells; In vitro;

机译：5-（2-嘧啶）-1H-四唑;钌;HELA细胞;体外;

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1. Synthesis of a Ruthenium(II) Compound based on 5-(2-Pyrimidyl)-1H-tetrazole for Photodynamic Therapy [J] . Wei Bo, Guo Meng Yue, Lu Yi Ming, Zeitschrift fur Anorganische und Allgemeine Chemie . 2018,第1期

机译：基于5-（2-嘧啶）-1H-四唑用于光动力治疗的钌（II）化合物的合成
2. A novel photosensitizer based on a ruthenium(ii) phenanthroline bis(perylenediimide) dyad: synthesis, generation of singlet oxygen and in vitro photodynamic therapy [J] . Aksakal Nuray Esra, Kazan Hasan Huseyin, Ecik Esra Tanriverdi, New Journal of Chemistry . 2018,第21期

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3. Synthesis, photophysical properties and in vitro evaluation of a chlorambucil conjugated ruthenium(II) complex for combined chemo-photodynamic therapy against HeLa cells [J] . Zhang Jing-Xiang, Pan Mei, Su Cheng-Yong Journal of Materials Chemistry, B. materials for biology and medicine . 2017,第24期

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4. Combining performance with thermal stability: Synthesis and characterization of 5-(3,5-dinitro-1H-pyrazol-4-yl)-1H-tetrazole and its energetic derivatives [C] . Maximilian Benz, Thomas M. Klapoetke, Joerg Stierstorfer Seminar on new trends in research of energetic materials . 2020

机译：性能兼具热稳定性：5-（3,5-二硝基-1H-吡唑-4-基）-1H-四唑及其高能衍生物的合成与表征
5. Photochemistry of group 8 metal complexes of type [M(bpy)2 cyanogen] (M = iron, ruthenium). Photosynthesis of heteroleptic iron(II) compounds and photoionization of ruthenium(II) compounds, or, Photoassisted synthesis of heteroleptic iron(II) compounds and photoionization of ruthenium(II) complexes. [D] . Turner, David Benjamin. 2009

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6. Synthesis and Supramolecular Structure of a (5-(3-(1H-tetrazol-5-yl)phenyl)-1H-tetrazole) Cobalt Complex [O] . George E. Kostakis, Christopher E. Anson, Annie K. Powell 2010

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机译：光动力学反应中的能量转移。 I.视网膜的光动力学敏感性。 II。光动力学和癌症。 III。非生物条件下氨基酸的光化学合成

Synthesis of a Ruthenium(II) Compound based on 5-(2-Pyrimidyl)-1H-tetrazole for Photodynamic Therapy

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