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首页> 外文期刊>Zeitschrift fur Arznei- und Gewurzpflanzen >Group-based, individualized, comprehensive core stability and balance intervention provides immediate and long-term improvements in walking in individuals with multiple sclerosis: A randomized controlled trial
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Group-based, individualized, comprehensive core stability and balance intervention provides immediate and long-term improvements in walking in individuals with multiple sclerosis: A randomized controlled trial

机译：基于小组的，个性化，综合核心稳定性和平衡干预提供了在具有多发性硬化症的个体中行走的立即和长期改善：随机对照试验

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Objectives Walking impairments are common in individuals with multiple sclerosis. Trunk control is a prerequisite for walking; however, knowledge regarding whether core stability and balance training influence walking is limited. This study aimed to investigate the immediate and long-term effects of a group-based, individualized, comprehensive core stability and balance intervention (GroupCoreDIST) compared with those of standard care on walking. Methods This assessor-blinded, prospective randomized controlled trial included 80 participants (Expanded Disability Status Scale scores 1-6.5) randomly allocated to GroupCoreDIST, conducted in groups of three for 60 min three times per week for 6 weeks (18 sessions) or standard care (n = 40/40). One participant attended no posttests, leaving 79 subjects for intention-to-treat analysis. The assessments were performed at baseline and at Weeks 7, 18, and 30. Outcomes included the 2-min walk test (2MWT), 10-m walk test-preferred/fast/slow speed (10MWT), Multiple Sclerosis Walking Scale-12 (MSWS-12), Patient Global Impression of Change-walking (PGIC-walking), Rivermead Visual Gait Assessment (RVGA), and ActiGraphsWgt3X-BT activity monitors (ActiGraph). The statistical analyses included repeated-measures mixed models performed in IBM SPSS Version 24. Results There were no significant between-group differences in the outcome measurements at baseline. The mean differences between groups were significant at all follow-up time points in favour of GroupCoreDIST for the 2MWT, 16.7 m at 7 weeks (95% CI [8.15, 25.25], 15.08 m at 18 weeks (95% CI [6.39, 23.77]) and 16.38 m at 30 weeks (95% CI [7.65, 25.12]; and the PGIC-walking, 0.89 points at 7 weeks (95% CI [1.34, 0.45]), 0.97 points at 18 weeks (95% CI [1.42, 0.52]), and 0.93 points at 30 weeks (95% CI [1.39, 0.48]; all p <= .001). The 10MWT-fast speed and the MSWS-12 showed significant between-group differences at 7 and 18 weeks and the RVGA at 7 weeks. No between-group differences were found regarding activity level (ActiGraph) or the 10MWT-preferred or slow speed. Conclusion Compared with standard care, GroupCoreDIST significantly improved walking immediately after the intervention for up to 24 weeks of follow-up.
机译：目标走路损伤在具有多发性硬化的个体中是常见的。树干控制是步行的先决条件;然而，关于核心稳定性和平衡训练的知识是否有限。该研究旨在调查基于团体，个性化，全面的核心稳定性和平衡干预（Groupcoredist）的立即和长期影响与行走的标准护理相比。方法对评估盲目的预期随机控制试验包括80名参与者（扩展残疾人状态规模分数1-6.5），随机分配给Groupcoredist，每周三次以3次为60分钟进行6周（18次）或标准护理（n = 40/40）。一名参与者没有出席后期，留下79名受试者进行意向治疗分析。评估在基线和数周，18周和30周内进行。结果包括2分钟的步道（2MWT），10米的步行试验优选/快速/慢速（10MWT），多发性硬化行走量表-12 （MSWS-12），患者全球变更步行（PGIC步行）的印象，rivermead视觉步态评估（RVGA）和Actigraphswgt3X-BT活动监视器（Actigraph）。统计分析包括在IBM SPSS版本24中进行的重复测量混合模型。结果在基线的结果测量中没有显着的差异。基团之间的平均差异在所有后续时间点，有利于2MWT的2MWT，16.7M，在7周（95％CI [8.15,25.25]，15.08m，18周（95％CI [6.39,23.77） ]）和30周（95％CI [7.65,25.12];和PGIC步行，7周的0.89点（95％CI [1.34,0.45]），在18周的0.97点（95％CI [ 1.42,0.52]），30周（95％CI [1.39,0.48];所有P <= .001）。10MWT-FAST速度和MSWS-12在7和18之间的差异显现出显着周和rvga在7周内。发现关于活动水平（Actigraph）或10MWT-优选或慢速的组之间的差异。结论与标准护理相比，Groupcoredist在干预后立即改善了长达24周后立即行走跟进。

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