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首页> 外文期刊>HIV medicine >Improvement in lipids after switch to boosted atazanavir or darunavir in children/adolescents with perinatally acquired HIV HIV on older protease inhibitors: results from the Pediatric HIV HIV / AIDS AIDS Cohort Study
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Improvement in lipids after switch to boosted atazanavir or darunavir in children/adolescents with perinatally acquired HIV HIV on older protease inhibitors: results from the Pediatric HIV HIV / AIDS AIDS Cohort Study

机译：改善脂质后，在较旧的蛋白酶抑制剂上占用HIV艾滋病毒的儿童/青少年在儿童/青少年中提高脂质：艾滋病毒艾滋病毒/艾滋病艾滋病辅助研究的结果

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Objectives Dyslipidaemia is common in perinatally HIV ‐infected ( PHIV ) youth receiving protease inhibitors ( PI s). Few studies have evaluated longitudinal lipid changes in PHIV youth after switch to newer PI s. Methods We compared longitudinal changes in fasting lipids [total cholesterol ( TC ), triglycerides ( TG ), low‐density lipoprotein cholesterol ( LDL ‐C), high‐density lipoprotein cholesterol ( HDL ‐C), and TC : HDL ‐C ratio] in PHIV youth enrolled in the Pediatric HIV / AIDS Cohort Study ( PHACS ) Adolescent Master Protocol ( AMP ) study who switched to atazanavir/ritonavir ( ATV /r)‐ or darunavir/ritonavir ( DRV /r)‐based antiretroviral therapy ( ART ) from an older PI ‐based ART and those remaining on an older PI . Generalized estimating equation models were fitted to assess the association of a switch to ATV /r‐ or DRV /r‐based ART with the rate of change in lipids, adjusted for potential confounders. Results From 2007 to 2014, 47 PHIV children/adolescents switched to ATV /r or DRV /r, while 120 remained on an older PI [primarily lopinavir/r (72%) and nelfinavir (24%)]. Baseline age ranged from 7 to 21 years. After adjustment for age, Tanner stage, race/ethnicity, and HIV RNA level, a switch to ATV /r or DRV /r was associated with a more rapid annual rate of decline in the ratio of TC : HDL ‐C. ( β = ?0.12; P = 0.039) than remaining on an older PI . On average, TC declined by 4.57 mg/ dL /year ( P = 0.057) more in the switch group. A switch to ATV /r or DRV /r was not associated with the rate of HDL ‐C, LDL ‐C, or TG change. Conclusions A switch to ATV /r or DRV /r may result in more rapid reduction in TC and the TC : HDL ‐C ratio in PHIV youth, potentially impacting long‐term cardiovascular disease risk.
机译：目的血脂血症在不受约束的HIV-infed（PHIV）青少年接受蛋白酶抑制剂（PI S）中常见。在切换到更新PI S之后，少数研究评估了PHIV青少年的纵向脂质变化。方法与铆接脂质的纵向变化比较[总胆固醇（TC），甘油三酯（TG），低密度脂蛋白胆固醇（LDL -C），高密度脂蛋白胆固醇（HDL -C）和TC：HDL -C比率]在PHIV青年中纳入儿科艾滋病毒/艾滋病队列研究（PHACS）青少年母体协议（AMP）研究，谁转向ATAZANAVIR / Ritonavir（ATV / R） - 或Darunavir / Ritonavir（DRV / R）基于抗逆转录病毒治疗（ART）从较旧的PI基础的艺术和留在较旧的PI上的艺术。广义估计方程模型被装配以评估切换到ATV / R-或DRV / R基领域的关联，以脂质的变化率调整，用于潜在的混凝剂。结果来自2007年至2014年，47个Phiv儿童/青少年切换到ATV / R或DRV / R，而120留在较旧的PI [主要是Lopinavir / R（72％）和Nelfinavir（24％）]。基线时代范围为7至21岁。调整年龄，Tanner阶段，种族/种族和HIV RNA水平后，转换到ATV / R或DRV / R与TC：HDL -C的比率的年度下降率更快。 （β=？0.12; p = 0.039）比较旧的PI剩余。平均而言，交换机组中，TC在4.57 mg / dl /年（p = 0.057）下降。转换到ATV / R或DRV / R与HDL -C，LDL -C或TG变化的速率无关。结论ATV / R或DRV / R的切换可能导致TC和TC：HDL-C比率在PHIV青年中的效率更快，可能影响长期心血管疾病风险。

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