Biolabeling with cobaltocinium tags

SusanneMüller-Bomke; MichaelSperling; HeikoHayen; UweKarst

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Biolabeling with cobaltocinium tags

机译：与钴腈的Biolabeling

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摘要

A label for amino and thiol functionalities of peptides and proteins based on the activated cobaltocinium hexafluorophosphate succinimide ester (CoS) is presented. Despite the known selectivity of a succinimide ester towards amines, CoS also modifies cysteine residues under the same reaction conditions. The derivatized biomolecules were investigated using liquid chromatography with subsequent electrospray-mass spectrometric detection (LC/ESI-MS). In combination with their remarkable stability under physiological conditions, easy handling and good spectroscopic properties, cobaltocinium ions provide all requirements for a powerful labeling reagent. Furthermore, in direct comparison to the isoelectronic well-established ferrocene reagents, the higher redox potential and the chemical stability of the cobaltocinium moiety add to the benefits as a derivatizing agent for bioanalysis.

机译：介绍了基于活化的六氟磷酸甲酸甲酰胺酯（COS）的肽和蛋白质的氨基和硫醇功能的标记。尽管琥珀酰亚胺酯的已知选择性朝向胺，COS也在相同的反应条件下修饰半胱氨酸残基。使用液相色谱法使用随后的电喷雾质谱检测（LC / ESI-MS）来研究衍生的生物分子。结合其在生理条件下的显着稳定性，易于处理和良好的光谱性质，钴腈离子提供了强大的标记试剂的所有要求。此外，与异形良好的二茂铁试剂直接比较，氧化铈潜力较高和钴杂化物部分的化学稳定性增加了作为生物分析的衍生剂的益处。

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《Zeitschrift fur Naturforschung, B. A Journal of Chemical Sciences》 |2018年第11期|共11页
作者
SusanneMüller-Bomke; MichaelSperling; HeikoHayen; UweKarst;
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作者单位

Westf?lische Wilhelms-Universit?t Münster Institute of Inorganic and Analytical Chemistry Corrensstra?e 30 48149 Münster Germany;

Westf?lische Wilhelms-Universit?t Münster Institute of Inorganic and Analytical Chemistry Corrensstra?e 30 48149 Münster Germany;

Westf?lische Wilhelms-Universit?t Münster Institute of Inorganic and Analytical Chemistry Corrensstra?e 30 48149 Münster Germany;

Westf?lische Wilhelms-Universit?t Münster Institute of Inorganic and Analytical Chemistry Corrensstra?e 30 48149 Münster Germany;

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正文语种 eng
中图分类化学;
关键词
amines; biolabeling; cobaltocinium; electrospray ionization-mass spectrometry (ESI-MS); thiols;

机译：胺;生物植物;钴杂化;电喷雾电离质谱（ESI-MS）;硫醇;

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专利

1. Biolabeling with cobaltocinium tags [J] . SusanneMüller-Bomke, MichaelSperling, HeikoHayen, Zeitschrift fur Naturforschung, B. A Journal of Chemical Sciences . 2018,第11期

机译：与钴腈的Biolabeling
2. Blue and red shift hydrogen bonds in crystalline cobaltocinium complexes [J] . Eliano Diana, Michele R. Chierotti, Edoardo M. C. Marchese New Journal of Chemistry . 2012,第4期

机译：结晶钴crystalline配合物中的蓝色和红色转移氢键
3. Fluorescent quantum dots-zika virus hybrid nanoconjugates for biolabeling, bioimaging, and tracking host-cell interactions [J] . Carvalho Sandhra M., Mansur Alexandra A. P., Carvalho Isadora C., Materials Letters . 2020,第Octa15期

机译：用于生物标记，生物成像和跟踪宿主细胞相互作用的荧光量子点 - Zika病毒杂交纳米缀合物
4. Upconversion fluorescence tyrosine doped LaF_3:Dy quantum dots useful in biolabeling and biotagging [C] . Amit T. Singh, M. M. Khandpekar DAE Solid State Physics Symposium . 2018

机译：上转换荧光酪氨酸掺杂Laf_3：Dy量子点在生物标记和生物造造中
5. Zero-dimensional (0D), one-dimensional (1D) and two-dimensional (2D) nanostructures for sustainable energy production and biolabeling applications. [D] . Wolcott, Abraham. 2009

机译：零维（0D），一维（1D）和二维（2D）纳米结构，用于可持续的能源生产和生物标记应用。
6. Nanometer-Sized Diamond Particle as a Probe for Biolabeling [O] . Jui-I. Chao, Elena Perevedentseva, Pei-Hua Chung, 2007

机译：纳米级金刚石颗粒作为生物标记探针
7. Nano interface potential influences in CdTe quantum dots and biolabeling [O] . S. Kanagasubbulakshmi, K. Kadirvelu 2018

机译：CDTE量子点和生物标记中的纳米界面电位影响

Biolabeling with cobaltocinium tags

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