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首页> 外文期刊>Dermatologic therapy >A prospective observational study to compare efficacy of topical triamcinolone acetonide 0.1% oral paste, oral methotrexate, and a combination of topical triamcinolone acetonide 0.1% and oral methotrexate in moderate to severe oral lichen planus
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A prospective observational study to compare efficacy of topical triamcinolone acetonide 0.1% oral paste, oral methotrexate, and a combination of topical triamcinolone acetonide 0.1% and oral methotrexate in moderate to severe oral lichen planus

机译：一种前瞻性观察性研究，以比较局部曲氨醇氨基酮0.1％口服糊剂，口服甲氨蝶呤的疗效，以及局部Triamcinolone丙酮酮0.1％和口服甲氨蝶呤的组合，中等至重度口服地衣平面图

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摘要

Abstract Topical corticosteroids are considered to be the most effective treatment for oral lichen planus (OLP). Methotrexate has been found to be effective in extensive cutaneous lichen planus. The objectives of the study were to evaluate the clinical efficacy and safety of topical triamcinolone 0.1% oral paste, oral methotrexate and a combination of these in symptomatic moderate‐to‐ severe OLP. Forty‐five patients were recruited and were allocated to three treatment arms with 15 patients in each treatment arm. They were treated for a period of 16 weeks or until complete clinical remission, whichever was earlier. The parameters assessed were clinical severity score, visual analogue score, and quality of life impairment questionnaire score. Forty‐three patients completed the study. All three treatment modalities were effective. The patients in the combination group had significantly better reduction in the outcome parameters assessed compared to the other two groups. Nine patients achieved complete clinical remission, 6 in the combination group and 3 in the topical triamcinolone group. Systemic methotrexate, alone or in combination with topical triamcinolone, is effective in management of moderate to severe OLP.
机译：摘要局部皮质类固醇被认为是口服地衣直升机（OLP）最有效的治疗方法。已发现甲氨蝶呤在广泛的皮肤地衣平面上有效。该研究的目标是评估局部曲米醇0.1％口服糊剂，口服甲氨蝶呤的临床疗效和安全性，以及这些在症状中等至严重的OLP中的组合。招募了四十五名患者，并分配到三个治疗臂，每次治疗臂15名患者。它们被治疗了16周或直至完整的临床缓解，以较早者为准。评估的参数是临床严重程度评分，视觉模拟分数和寿命损伤问卷评分的质量。四十三名患者完成了这项研究。所有三种治疗方式都有效。与其他两组相比，组合组中的患者显着降低了评估的结果参数。九名患者在联合组和3中达到了完整的临床缓解，在局部曲米醇组中。 Systemic甲氨蝶呤，单独或与局部Triamcinolone组合，在中度至严重OLP的管理方面都是有效的。

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  • 来源
    《Dermatologic therapy》 |2018年第1期|共6页
  • 作者

    Chauhan P.; De D.; Handa S.; Narang T.; Saikia U. N.;

  • 作者单位

    Department of Dermatology Venereology and LeprologyPostgraduate Institute of Medical Education and;

    Department of Dermatology Venereology and LeprologyPostgraduate Institute of Medical Education and;

    Department of Dermatology Venereology and LeprologyPostgraduate Institute of Medical Education and;

    Department of Dermatology Venereology and LeprologyPostgraduate Institute of Medical Education and;

    Department of HistopathologyPostgraduate Institute of Medical Education and ResearchChandigarh India;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 皮肤病学与性病学;
  • 关键词

    oral lichen planus; moderate to severe; triamcinolone acetonide; methotrexate;

    机译：口服地衣直升机;中度至严重;脂肪醇酮酮;甲氨蝶呤;

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