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首页> 外文期刊>Alcohol >Lack of effect of nucleus accumbens dopamine D1 receptor blockade on consumption during the first two days of operant self-administration of sweetened ethanol in adult Long-Evans rats
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Lack of effect of nucleus accumbens dopamine D1 receptor blockade on consumption during the first two days of operant self-administration of sweetened ethanol in adult Long-Evans rats

机译：伏伏核对多巴胺D1受体的阻断对成年Long-Evans大鼠操作性甜味乙醇自我施药前两天的消耗缺乏影响

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The mechanisms underlying ethanol self-administration are not fully understood; however, it is clear that ethanol self-administration stimulates nucleus accumbens dopamine release in well-trained animals. During operant sweetened ethanol self-administration behavior, an adaptation in the nucleus accumbens dopamine system occurs between the first and second exposure, paralleling a dramatic increase in sweetened ethanol intake, which suggests a single exposure to sweetened ethanol may be sufficient to learn the association between sweetened ethanol cues and its reinforcing properties. In the present experiment, we test the effects of blockade of nucleus accumbens dopamine D1 receptors on operant sweetened ethanol self-administration behavior during the first 2 days of exposure. Adult male Long-Evans rats were first trained to self-administer 10% sucrose (10S) across 6 days in an appetitive and consummatory operant model (appetitive interval: 10-min pre-drinking wait period and a lever response requirement of 4; consummatory interval: 20-min access to the drinking solution). After training on 10S, the drinking solution was switched to 10% sucrose plus 10% ethanol (10S10E); control rats continued drinking 10S throughout the experiment. Bilateral nucleus accumbens microinjections of the dopamine D1 antagonist, SCH-23390 (0, 1.0, or 3.0 mu g/side), immediately preceded the first two sessions of drinking 10S10E. Results show that blocking nucleus accumbens dopamine D1 receptors has little or no influence on consumption during the first 2 days of exposure to the sweetened ethanol solution or maintenance of sucrose-only drinking. Furthermore, the high dose of SCH-23390, 3.0 mu g/side, reduced open-field locomotor activity. In conclusion, we found no evidence to suggest that nucleus accumbens DI receptor activation is involved in consumption of a sweetened ethanol solution during the first 2 days of exposure or maintenance of sucrose drinking, but rather D1 receptors seem necessary for general locomotor activity that contributes to initiation of appetitive behavior. (C) 2015 Elsevier Inc. All rights reserved.
机译：乙醇自我管理的机制尚不完全清楚。但是，很明显，乙醇的自我给药可以刺激训练有素的动物中伏隔核多巴胺的释放。在操作性甜化乙醇自我给药行为期间，伏安核多巴胺系统在第一次和第二次暴露之间发生适应，同时甜味乙醇摄入量急剧增加，这表明单次暴露于甜味乙醇可能足以了解两者之间的联系。甜味乙醇提示及其增强性能。在目前的实验中，我们测试了伏隔核多巴胺D1受体的阻断在暴露的前2天对有效甜味乙醇自我施用行为的影响。首先对成年雄性Long-Evans大鼠进行训练，使其在一个具有竞争性和完善性的操作模型中（竞争性间隔：饮酒前的等待时间为10分钟，杠杆反应要求为4;具有吸收性），为期6天自给10％蔗糖（10S）。间隔：20分钟可进入饮用溶液）。在10S训练后，将饮用溶液切换为10％蔗糖加10％乙醇（10S10E）;对照大鼠在整个实验中继续喝10S。多巴胺D1拮抗剂SCH-23390（0、1.0或3.0μg /侧）的伏隔核双侧注射是在饮用10S10E的前两节之前。结果表明，封闭伏伏核多巴胺D1受体在暴露于甜味乙醇溶液的前两天或维持仅蔗糖的饮用过程中，对摄入量几乎没有影响。此外，高剂量的SCH-23390（每侧3.0微克）降低了开放磁场的运动活性。总之，我们没有发现证据表明伏隔核DI受体的活化与暴露或维持蔗糖饮用的前2天消耗了甜味的乙醇溶液有关，但是D1受体似乎是一般运动能力所必需的，这有助于引发食欲行为。 （C）2015 Elsevier Inc.保留所有权利。

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