...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Alcohol >Green tea protects against ethanol-induced lipid peroxidation in rat organs.
【24h】

Green tea protects against ethanol-induced lipid peroxidation in rat organs.

机译：绿茶可防止乙醇诱导的大鼠器官脂质过氧化。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Ethanol metabolism is accompanied by generation of free radicals, which stimulates lipid peroxidation. Natural antioxidants are particularly useful in such a situation. The current study was designed to investigate the efficacy of green tea, as a source of water-soluble antioxidants (catechins), on lipid peroxidation in liver, brain, and blood induced by chronic (4 weeks) ethanol intoxication in rats. Feeding of ethanol led to a significant increase in lipid peroxidation, as measured by increased concentrations of lipid hydroperoxides, 4-hydroxynonenal, and malondialdehyde. Feeding of ethanol also changed the glutathione-dependent lipid hydroperoxide decomposition system, resulting in a decrease in both reduced glutathione concentration and activity of glutathione peroxidase. Observed changes were statistically significant in all examined tissues. Enhancement in lipid peroxidation was associated with disruption of hepatocyte cell membranes, as observed through electron microscopic evaluation. Green teaprotects phospholipids from enhanced peroxidation and prevents changes in biochemical parameters and morphologic changes observed after ethanol consumption. These results support the suggestion that green tea protects membranes from peroxidation of lipids associated with ethanol consumption.
机译：乙醇代谢伴随自由基的产生，从而刺激脂质过氧化。天然抗氧化剂在这种情况下特别有用。当前的研究旨在调查作为水溶性抗氧化剂（儿茶素）来源的绿茶对大鼠慢性（4周）乙醇中毒所致肝，脑和血液中脂质过氧化的功效。通过增加脂质氢过氧化物，4-羟基壬烯醛和丙二醛的浓度来测量，乙醇的供给导致脂质过氧化的显着增加。乙醇的添加也改变了谷胱甘肽依赖性脂质氢过氧化物分解系统，导致减少的谷胱甘肽浓度和谷胱甘肽过氧化物酶活性降低。在所有检查的组织中观察到的变化在统计学上均具有统计学意义。如通过电子显微镜评估所观察到的，脂质过氧化作用的增强与肝细胞膜的破坏有关。绿茶可以保护磷脂免于增强的过氧化作用，并防止乙醇消耗后观察到的生化参数变化和形态变化。这些结果支持了这样的建议，即绿茶可以保护膜免受与乙醇消耗相关的脂质的过氧化作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号