...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Human gene therapy >DNA Vaccine-Induced Long-Lasting Cytotoxic T Cells Targeting Conserved Elements of Human Immunodeficiency Virus Gag Are Boosted Upon DNA or Recombinant Modified Vaccinia Ankara Vaccination
【24h】

DNA Vaccine-Induced Long-Lasting Cytotoxic T Cells Targeting Conserved Elements of Human Immunodeficiency Virus Gag Are Boosted Upon DNA or Recombinant Modified Vaccinia Ankara Vaccination

机译：DNA疫苗诱导的持久性细胞毒性T细胞靶向人免疫缺陷病毒GAG的保守元素，在DNA或重组改性的痘苗病症Ankara疫苗接种时升高

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

DNA-based vaccines able to induce efficient cytotoxic T-cell responses targeting conserved elements (CE) of human immunodeficiency virus type 1 (HIV-1) Gag have been developed. These CE were selected by stringent conservation, the ability to induce T-cell responses with broad human leukocyte antigen coverage, and the association between recognition of CE epitopes and viral control in HIV-infected individuals. Based on homology to HIV, a simian immunodeficiency virus p27(gag) CE DNA vaccine has also been developed. This study reports on the durability of the CE-specific T-cell responses induced by HIV and simian immunodeficiency virus CE DNA-based prime/boost vaccine regimens in rhesus macaques, and shows that the initially primed CE-specific T-cell responses were efficiently boosted by a single CE DNA vaccination after the long rest period (up to 2 years). In another cohort of animals, the study shows that a single inoculation with non-replicating recombinant Modified Vaccinia Ankara (rMVA62B) also potently boosted CE-specific responses after around 1.5 years of rest. Both CE DNA and rMVA62B booster vaccinations increased the magnitude and cytotoxicity of the CE-specific responses while maintaining the breadth of CE recognition. Env produced by rMVA62B did not negatively interfere with the recall of the Gag CE responses. rMVA62B could be beneficial to further boosting the immune response to Gag in humans. Vaccine regimens that employ CE DNA as a priming immunogen hold promise for application in HIV prevention and therapy.
机译：已经开发出能够诱导靶向保守元素（CE）的有效细胞毒性T细胞应答的基于DNA的疫苗已经开发出1型（HIV-1）Gag的保守元素（CE）。这些CE是由严格的保护选择的，能够诱导具有宽人白细胞抗原覆盖率的T细胞应答，以及艾滋病毒感染个体中CE表位和病毒对照之间的关联。基于对HIV的同源性，还开发了一种SIMIAN免疫缺陷病毒P27（GAG）CE DNA疫苗。本研究报告了HIV和SIMIAN免疫缺陷病毒CE DNA的PROST患者CE DNA的诱导诱导的CE特异性T细胞应答的耐久性，并表明最初灌注的CE特异性T细胞应答有效在长期休息期后（长达2年）后，通过单一CE DNA疫苗接种疫苗。在另一种动物队列中，该研究表明，在休息1.5年后，单次与非复制重组改性痘苗病毒Ankara（RMVA62B）也有效地升高了CE特异性反应。 CE DNA和RMVA62B增强疫苗接种疫苗接种增加了CE特定响应的幅度和细胞毒性，同时保持CE识别的宽度。由RMVA62B产生的ENV没有对GAG CE反应的召回产生负面干扰。 RMVA62B可能有益于进一步提高对人类堵塞的免疫应答。使用CE DNA的疫苗方案作为引发免疫原性的诱导应用在艾滋病毒预防和治疗中的应用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号