...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Alcohol >Acute mild footshock alters ethanol drinking and plasma corticosterone levels in C57BL/6J male mice, but not DBA/2J or A/J male mice.
【24h】

Acute mild footshock alters ethanol drinking and plasma corticosterone levels in C57BL/6J male mice, but not DBA/2J or A/J male mice.

机译：急性轻度休克改变了C57BL / 6J雄性小鼠的乙醇饮用量和血浆皮质酮水平，但不改变DBA / 2J或A / J雄性小鼠。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Stress is an often-reported cause for alcohol consumption in humans. Acute intermittent footshock is a frequently used paradigm to produce stress in laboratory animals including mice. The effect produced by intermittent footshock stress on ethanol self-administration has been inconsistent: both increases and decreases in ethanol consumption have been reported. The current set of studies further investigates, in three commonly studied mouse strains, the effect of footshock stress on ethanol self-administration. Furthermore, the effect of footshock on plasma corticosterone levels was determined to investigate potential biochemical correlates. Adult male C57BL/6J, DBA/2J, and A/J mice were allowed to self-administer 10% (wt/vol) ethanol for 12 days in a standard 23-h two-bottle paradigm before receiving either 15 min of mild inescapable footshock or no footshock. Shock intensity was equal to the mean intensity at which each strain vocalized as previously determined. Following footshock, animals had the opportunity to self-administer ethanol for an additional 23 h. Separate animals were subjected to either footshock or no shock prior to collection of plasma for corticosterone. Mild footshock stress altered ethanol self-administration and increased plasma corticosterone levels in C57BL/6J mice. Footshock stress did not alter ethanol self-administration or plasma corticosterone levels in DBA/2J or A/J mice. These data demonstrate that mild footshock stress is a suboptimal method of modeling the stress-induced increases in ethanol consumption often reported by humans.
机译：压力是人类经常饮酒的原因。急性间歇性足震是在包括小鼠在内的实验动物中产生压力的一种常用范例。间歇性的休克压力对乙醇自我管理的影响一直不一致：已经报道了乙醇消耗量的增加和减少。当前的一组研究进一步研究了三种常见的小鼠品系中，休克应激对乙醇自我给药的影响。此外，确定了休克对血浆皮质酮水平的影响，以研究潜在的生化相关性。允许成年雄性C57BL / 6J，DBA / 2J和A / J小鼠在标准的23小时两瓶范式中自施用10％（wt / vol）乙醇12天，然后接受15分钟的不可避免的轻度不可避免触电或无触电。冲击强度等于每个应变发声的平均强度，如先前确定。休克后，动物还有机会自行补充乙醇23小时。在收集血浆皮质酮之前，对单独的动物进行休克或不进行电击。轻度的足部震荡改变了C57BL / 6J小鼠的乙醇自我管理并增加了血浆皮质酮水平。休克应激不会改变DBA / 2J或A / J小鼠的乙醇自我给药或血浆皮质酮水平。这些数据表明，轻微的休克压力是模拟人类经常报道的乙醇引起的压力诱导乙醇消费增加的次佳方法。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号