目的:探讨急性脑梗死病人血浆同型半胱氨酸、超敏C反应蛋白、D-二聚体、脂蛋白a水平的改变及临床意义.方法:选自我院于2015-06~2016-06期间收治的急性脑梗死病人84例,同期选自我院于2015-06~2016-06期间的健康体检者60例作为对照组.检测血浆同型半胱氨酸、超敏C反应蛋白、D-二聚体、脂蛋白a含量.结果:观察组血浆同型半胱氨酸、超敏C反应蛋白、D-二聚体及脂蛋白a含量明显高于对照组,均有统计学差异(P<0.05);观察组同型半胱氨酸、超敏C反应蛋白、D-二聚体及脂蛋白a阳性率高于对照组,均有统计学差异(P<0.05);大面积梗死组血浆同型半胱氨酸、超敏C反应蛋白、D-二聚体及脂蛋白a含量高于中面积梗死组和小面积梗死组,中面积梗死组血清同型半胱氨酸、超敏C反应蛋白、D-二聚体及脂蛋白a含量高于小面积梗死组,均有统计学差异(P<0.05).结论:血浆同型半胱氨酸、超敏C反应蛋白、D-二聚体、脂蛋白a水平与急性脑梗死病情发生、发展密切相关.%Objective:To investigate the changes and clinical significance of plasma homocysteine,high-sensitivity C reactive protein(hs-CRP),D-D dimer and a in patients with acute cerebral infarction.Methods:84 patients with acute cerebral infarction admitted in our hospital from June 2015 to 2016 in were selected from the same period in our hospital in the period of 2016 in the year of June in June 2015 as the control group.Detection of plasma homocysteine,high sensitive C reactive protein,D-D polymer,lipoprotein a content.Results:the observation group of plasma homocysteine and high-sensitivity C reactive protein,two D-D dimer and apolipoprotein A were significantly higher than the control group(P<0.05);homocysteine and high-sensitivity C reactive protein,two D-dimer and lipoprotein a were higher than that of control group(P<0.05);large area infarction group homocysteine,high sensitive C reactive protein,two D-D dimer and lipoprotein a were higher than in the area of infarction group and small infarct group,in the area of infarction group serum homocysteine and high-sensitivity C reactive protein,two D-D dimer and lipoprotein a content higher than the small area infarction group were statistically significant(P<0.05).Conclusion:the levels of plasma homocysteine,high-sensitivity C reactive protein,D-D dimer and a are closely related to the occurrence and development of acute cerebral infarction.
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