...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Developmental Medicine and Child Neurology >Fetal surgical intervention for myelomeningocele: lessons learned, outcomes, and future implications
【24h】

Fetal surgical intervention for myelomeningocele: lessons learned, outcomes, and future implications

机译：Myelomeningocele的胎儿外科介入：学习，结果和未来的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Fetal myelomeningocele (fMMC) closure (spina bifida aperta) has become a care option for patients that meet inclusion criteria, but it is clear that fetal intervention, while improving outcomes, is not a cure. This review will: (1) focus on the rationale for fMMC surgery based on preclinical studies and observations that laid the foundation for human pilot studies and a randomized controlled trial; (2) summarize important clinical outcomes; (3) discuss the feasibility, efficacy, and safety of recent developments in fetal surgical techniques and approaches; and (4) highlight future research directions. Given the increased risk of maternal and fetal morbidity associated with prenatal intervention, accompanied by the increasing number of centres performing interventions worldwide, teams involved in the care of these patients need to proceed with caution to maintain technical expertise, competency, and patient safety. Ongoing assessment of durability of the benefits of fMMC surgery, as well as additional refinement of patient selection criteria and counselling, is needed to further improve outcomes and reduce the risks to the mother and fetus. What this paper adds High‐quality prospective studies are needed to broaden the indication for fetal surgery in the general myelomeningocele population. Innovative minimally invasive approaches have had promising results, yet lack comprehensive and robust experimental or clinical evaluation. Important information to help families make informed decisions regarding fetal surgery for myelomeningocele is provided.
机译：胎儿骨髓细胞（FMMC）闭合（Spina Bifida Aperta）已成为符合纳入标准的患者的护理选择，但很明显胎儿干预，同时改善结果并非治愈。本综述：（1）重点关注基于临床前研究和观察的FMMC手术的理由，为人类试验研究和随机对照试验为基础; （2）总结了重要的临床结果; （3）讨论胎儿手术技术和方法中最近发展的可行性，疗效和安全性; （4）突出未来的研究方向。鉴于与产前干预相关的孕产妇和胎儿发病率的风险增加，伴随着越来越多的全球活动的持续干预措施，参与关注这些患者的团队需要谨慎，以维持技术专长，能力和患者安全。需要评估FMMC手术的益处的持久性，以及额外的患者选择标准和咨询的额外改进，以进一步改善母亲和胎儿的风险。本文增加了高质量的前瞻性研究，以扩大胎儿培养茧群体中胎儿手术的指示。创新的微创方法具有很有希望的结果，但缺乏全面和稳健的实验或临床评价。有助于家庭的重要信息提供了有关骨髓培训中的胎儿手术的明智决定。

著录项

  • 来源
  • 作者

    Danzer Enrico; Joyeux Luc; Flake Alan W; Deprest Jan;

  • 作者单位

    Center for Fetal Diagnosis and TreatmentThe Children's Hospital of PhiladelphiaPhiladelphia PA USA;

    MyFetUZ Fetal Research CenterKU LeuvenLeuven Belgium;

    Center for Fetal Diagnosis and TreatmentThe Children's Hospital of PhiladelphiaPhiladelphia PA USA;

    MyFetUZ Fetal Research CenterKU LeuvenLeuven Belgium;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号