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首页> 外文期刊>Diabetic medicine: A journal of the British Diabetic Association >The glycaemic benefits of a very‐low‐carbohydrate ketogenic diet in adults with Type 1 diabetes mellitus may be opposed by increased hypoglycaemia risk and dyslipidaemia
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The glycaemic benefits of a very‐low‐carbohydrate ketogenic diet in adults with Type 1 diabetes mellitus may be opposed by increased hypoglycaemia risk and dyslipidaemia

机译：在1型糖尿病患者中，糖尿病患者中血糖酮尿的血糖益处可能会通过增加的低血症风险和血脂血症来相反

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Abstract Aims To investigate whether very‐low‐carbohydrate high‐fat diets, typical of ketogenic diets, can improve glycaemic control without causing any ill health effects in adults with Type 1 diabetes. Methods In this observational study, 11 adults with Type 1 diabetes (seven men, four women, mean ± sd age 36.1± 6.8 years, mean ± sd duration of diabetes 12.8 ± 10.3 years), who followed a ketogenic diet ( 55 g carbohydrate per day) for a mean ± sd of 2.6 ± 3.3 years (β‐hydroxybutyrate 1.6 ± 1.3 mmol/l), underwent sampling and analysis of fasting blood, and were fitted with a blinded continuous glucose monitor for 7 days to measure glycaemic variability. Results The mean ± sd HbA 1c levels were 35±4 mmol/mol (5.3±0.4%), and participants spent 74±20 and 3±8% of their time in the euglycaemic (4–8 mmol/l) and hyperglycaemic (10 mmol/l) ranges, respectively, with little daily glycaemic variability ( sd 1.5±0.7 mmol/l; coefficient of variation 26±8%). Blood glucose levels were 3.0 mmol/l for 3.6% of the time, and participants experienced a median (range) of 0.9 (0.0–2.0) daily episodes of hypoglycaemia. Total cholesterol, LDL cholesterol, total cholesterol/ HDL cholesterol ratio, and triglycerides were above the recommended range in 82%, 82%, 64% and 27% of participants, respectively; however, HDL cholesterol levels were within the recommended range for all participants. Participants displayed no or little evidence of hepatic or renal dysfunction. Conclusion This study provides the first evidence that, ketogenic diets in adults with Type 1 diabetes are associated with excellent HbA 1c levels and little glycaemic variability, but may also be associated with dyslipidaemia and a high number of hypoglycaemic episodes.
机译：摘要旨在探讨典型的酮饮食的典型碳水化合物高脂饮食是否可以改善血糖控制，而不会导致1型糖尿病的成人对成年人的任何健康作用。该观察性研究中的方法，11名患有1型糖尿病的成人（七名男性，4名女性，平均±6.8岁，平均±8±10.3岁），其次是酮饮食（＆ 55克每天碳水化合物）平均值±3.3岁（β-羟基丁酸盐1.6±1.3mmol / L），进行禁食血液的采样和分析，并致盲连续葡萄糖显示器7天，以测量血糖可变性。结果平均值±SD HBA 1C水平为35±4 mmol / mol（5.3±0.4％），参与者在EGLYCAIMIX（4-8mmol / L）和高血糖中花费74±20和3±8％（ ＆ 10 mmol / l）分别为每日血糖变异性少（SD 1.5±0.7mmol / L;变异系数26±8％）。血糖水平为3.6％的时间，参与者经历了0.9（0.0-2.0）的低血糖的日期（范围）。总胆固醇，LDL胆固醇，总胆固醇/ HDL胆固醇比和甘油三酯分别高于82％，82％，64％和27％的参与者的范围。然而，HDL胆固醇水平在所有参与者的推荐范围内。参与者没有显示肝脏或肾功能紊乱的缺点或少数证据。结论本研究提供了第一种证据表明，具有1型糖尿病的成人中的酮味饮食与优异的HBA 1C水平和少量血糖变异有关，但也可能与血脂血症和大量的低血糖发作有关。

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