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首页> 外文期刊>Alcohol and alcoholism: international journal of the Medical Council on Alcoholism >Clinical approach to intestinal maturation in neonates prenatally exposed to alcohol.
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Clinical approach to intestinal maturation in neonates prenatally exposed to alcohol.

机译：产前暴露于酒精的新生儿肠道成熟的临床方法。

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AIM: The need for a non-invasive diagnosis of the effects of ethanol in utero on the development of the intestine in humans led us to look for a serum marker of the structural integrity of the intestine. We propose apolipoprotein A-IV (apoA-IV) as a possible candidate. In humans this protein is synthesized only by intestinal mucosa, it is expressed in the enterocyte of the foetus from 20 weeks of gestation, and it is released to the blood stream after synthesis. METHODS: We measured the levels of apoA-IV in the umbilical cord serum of neonates whose mothers had consumed alcohol during pregnancy and neonates born to women who had not (controls).The gestational age at delivery of the cases studied ranged from 36 to 42 weeks. ELISA and Western blot analysis were used. RESULTS: There was no difference in the mean body weight of neonates from either group. Nevertheless, exposure to ethanol in utero significantly reduced (by about 30%) the apoA-IV levels in serum at birth, regardless of body weight. CONCLUSION: Our findings suggest that circulating apoA-IV levels could be used as a clinical marker of the prenatal effects of ethanol on the structural integrity of the intestine. Neonatal diagnosis of these intestinal effects could improve post-natal outcome.
机译：目的：需要对子宫内乙醇对人肠发育的影响进行非侵入性诊断，这促使我们寻找一种能检测肠结构完整性的血清标志物。我们提出载脂蛋白A-IV（apoA-IV）作为可能的候选药物。在人类中，这种蛋白质仅由肠粘膜合成，从妊娠20周开始在胎儿的肠上皮细胞中表达，并在合成后释放到血流中。方法：我们测量了母亲在怀孕期间饮酒的新生儿和未饮酒的女性（对照组）的脐带血清中apoA-IV的水平。本研究的分娩胎龄为36至42岁。周。使用ELISA和蛋白质印迹分析。结果：两组新生儿的平均体重无差异。然而，无论体重如何，出生时子宫内乙醇的暴露都会显着降低血清中apoA-IV水平（约30％）。结论：我们的发现提示循环中的apoA-IV水平可以用作乙醇对产前肠道结构完整性的临床标志。对这些肠道作用的新生儿诊断可以改善出生后的预后。

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