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首页> 外文期刊>Diagnostic microbiology and infectious disease >Serological and molecular detection of Mycoplasma pneumoniae in children with community-acquired lower respiratory tract infections
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Serological and molecular detection of Mycoplasma pneumoniae in children with community-acquired lower respiratory tract infections

机译：社区收购较低呼吸道感染儿童支原体肺炎的血清学和分子检测

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This study was designed to evaluate the incidence of Mycoplasma pneumoniae infection in children with community-acquired lower respiratory tract infections (LRTIs). A total of 245 patients 6 months to 12 years of age were investigated for M. pneumoniae employing serological tests, polymerase chain reaction (PCR), nested PCR, and reverse transcription PCR (RT-PCR) on throat swab samples. Forty five (59.2%) children = 5 years age group were positive for M. pneumoniae infection, and this difference was statistically significant (P <= 0.01). Clinical and radiological findings across M. pneumoniae-positive and -negative cases were comparable. Serology, PCR, nested PCR, and RT-PCR together detected M. pneumoniae infection in 76 (31%) patients. Sensitivity, specificity, and positive and negative predictive values of PCR were 16.18%, 95.48%, 57.89%, and 74.78%, respectively, and those of serology were 57.89%, 74.78%, 16.18%, and 95.48%, respectively. Serological and molecular detection in combination is useful for rapid and reliable diagnosis of M. pneumoniae infections in children with LRTIs. (C) 2019 Elsevier Inc. All rights reserved.
机译：本研究旨在评估患有社区收购的较低呼吸道感染（LRTIS）的儿童肺炎肺炎感染的发病率。对喉部试验，聚合酶链反应（PCR），巢式PCR和逆转录PCR（RT-PCR）进行血管学试验，聚合酶链反应（PCR），在咽棉样品中，共有245名患者6个月至12岁。四十五（59.2％）儿童= 5岁，年龄组对肺炎肺炎感染阳性，并且这种差异在统计学上显着（P <= 0.01）。肺炎肺炎肺炎患者阳性和阴道病例的临床和放射性。血清学，PCR，巢式PCR和RT-PCR在76名（31％）患者中检测到M.肺炎肺炎感染。 PCR的敏感性，特异性和正负预测值分别为16.18％，95.48％，57.89％和74.78％，血清学分别为57.89％，74.78％，分别为7.1％和95.48％。组合的血清学和分子检测对于LRTIS儿童的肺炎肺炎肺炎感染的快速可靠诊断。 （c）2019 Elsevier Inc.保留所有权利。

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