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Bupropion and nicotine patch as smoking cessation aids in alcoholics.

机译：安非他酮和尼古丁贴片可作为戒烟辅助酒精中毒者。

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This is a double-blind placebo-controlled study of sustained-release bupropion as a smoking cessation aid in alcoholics undergoing treatment for their alcoholism. Participants (N=58) were enrolled within 1 week of entry into alcohol treatment from community and Veterans Affairs Substance Use Disorder programs. All participants received nicotine patch and were invited to attend a smoking cessation lecture and group. Cigarette smoking and alcohol outcomes were measured at 6 months. Bupropion when added to nicotine patch did not improve smoking outcomes. One third of participants on bupropion reported discontinuing the drug during weeks 1-4. Participants reported cigarette outcomes with nicotine patch that are similar to those seen in the general population. All study participants significantly reduced cigarette use. Comorbid affective disorder or antipersonality disorder did not affect outcomes. Alcohol outcomes were improved in those who discontinued cigarettes.
机译：这是对正在接受酒精中毒治疗的酗酒者进行缓释安非他酮作为戒烟辅助剂的双盲安慰剂对照研究。参加者（N = 58）在社区和退伍军人事务物质使用障碍计划进入酒精治疗后的1周内入组。所有参与者均接受了尼古丁贴剂，并被邀请参加戒烟讲座和小组。在6个月时测量吸烟和饮酒结果。将安非他酮添加到尼古丁贴片中不会改善吸烟效果。安非他酮的三分之一参与者报告在1-4周内停用了该药物。参与者报告说，使用尼古丁贴剂的卷烟结局与普通人群相似。所有研究参与者均显着减少了吸烟量。合并症情感障碍或人格障碍不影响预后。戒烟者的酒精摄入量得到改善。

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