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首页> 外文期刊>Alcohol >Growth hormone response to the GABA-B agonist baclofen in 3-week abstinent alcoholics.
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Growth hormone response to the GABA-B agonist baclofen in 3-week abstinent alcoholics.

机译：在3周禁酒后，对GABA-B激动剂巴氯芬的生长激素反应。

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Gamma-aminobutyric acid (GABA) dysfunction is a known feature of alcoholism. We investigated GABA-B receptor activity in 3-week abstinent alcoholics using the growth hormone (GH) response to baclofen, a GABA-B receptor agonist. The study aimed to investigate the relationship between GABA-B receptor activity and alcohol withdrawal. GH response to baclofen was measured in alcohol-dependent males without depression (n = 22) who were on day 21 of alcohol abstinence and in healthy control male subjects (n = 23). After 20mg baclofen was given orally to the subjects, blood samples for GH assay were obtained every 30 min for the subsequent 150 min. The patients were divided into two subgroups (continuing withdrawal and recovered withdrawal subgroups) according to their withdrawal symptom severity scores on day 21 of alcohol cessation. Baclofen administration significantly altered GH secretion in the controls, but not in the patients. When GH response to baclofen was assessed as DeltaGH, it was lower in the patients with continuing withdrawal symptoms than in the controls and in the recovered withdrawal group. Impaired GH response to baclofen in all patients mainly pertained to the patients whose withdrawal symptoms partly continued. Our results suggest that reduced GABA-B receptor activity might be associated with longer-term alcohol withdrawal symptoms in alcoholic patients.
机译：γ-氨基丁酸（GABA）功能障碍是酗酒的已知特征。我们使用对GABA-B受体激动剂巴氯芬的生长激素（GH）反应，调查了3周禁酒后的GABA-B受体活性。该研究旨在研究GABA-B受体活性与戒酒之间的关系。在戒酒第21天且无抑郁的酒精依赖男性（n = 22）和健康对照男性受试者（n = 23）中测量了对巴氯芬的GH反应。给受试者口服20mg巴氯芬后，每30分钟采集一次GH分析用血样，随后进行150分钟。根据戒酒第21天的戒断症状严重程度评分，将患者分为两个亚组（持续戒断和恢复戒断亚组）。施用巴氯芬可显着改变对照组的GH分泌，但不能改变患者的GH分泌。当将对巴氯芬的GH反应评估为DeltaGH时，具有持续戒断症状的患者的GH反应低于对照组和康复戒断组的GH。在所有患者中对巴氯芬的GH应答受损主要与退出症状部分持续的患者有关。我们的结果表明，酒精中毒患者中GABA-B受体活性降低可能与长期戒酒症状相关。

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