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Mixing proteomics and alcohol.

机译:蛋白质组学和酒精混合。

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摘要

Techniques for high-throughput measurement of protein expression and posttranslational modification are just beginning to be applied to alcohol research. Studies using this proteomic approach to examine tissue from alcoholic humans and alcohol-exposed nonhuman primates have appeared in the last year. In the present issue of Alcohol, Bell et al. present the first such analysis of brain protein expression in relation to alcohol drinking in rodents. This study found changes in several interesting classes of proteins, including molecules involved in vesicular neurotransmitter release, cellular metabolism, and cell structure. These new and exciting findings are discussed in relation to the proteomics studies in primates, and the future of proteomics in the alcohol research field.
机译:用于蛋白质表达和翻译后修饰的高通量测量技术刚刚开始应用于酒精研究。去年,使用这种蛋白质组学方法检查酒精人和酒精暴露的非人类灵长类动物组织的研究已经出现。在本期《酒精》中,Bell等人。本研究首次对与啮齿类动物饮酒有关的脑蛋白表达进行了分析。这项研究发现了几种有趣的蛋白质类型发生了变化,包括参与水泡神经递质释放,细胞代谢和细胞结构的分子。这些新的令人振奋的发现与灵长类动物的蛋白质组学研究以及酒精研究领域中蛋白质组学的未来有关。

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