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首页> 外文期刊>AJRI: American Journal of Reproductive Immunology >Increased prevalence of IL-17-producing peripheral blood lymphocytes in pre-eclampsia.
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Increased prevalence of IL-17-producing peripheral blood lymphocytes in pre-eclampsia.

机译：子痫前期中产生IL-17的外周血淋巴细胞的患病率增加。

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PROBLEM: Systemic inflammation is a dominant component in the pathogenesis of pre-eclampsia. Besides the imbalance of Th1 and Th2 cells, alterations of the prevalence of Th17 and regulatory T cells have also been suggested to contribute to inflammation. We aimed to describe the prevalence of these four CD4 lymphocyte subtypes in pre-eclampsia and normal pregnancy, along with that of IL-17-producing CD8 and NK cells. METHOD OF STUDY: Twenty pre-eclamptic and 22 normal pregnant women were enrolled in this study. Using flow cytometry, we determined the prevalence of IL-17-producing cells among the CD4, CD8 and NK cell subsets. Furthermore, we measured the prevalence of CD4+ Tregs, and Th1/Th2 cells were characterized using cell surface chemokine receptor markers. RESULTS: We demonstrated that there is a shift not only in the Th1/Th2 but also in the Th17/Treg balance favouring skewness towards a pro-inflammatory status in pre-eclampsia. The proportion of CD8 and NK cells that express IL-17 was also higher in pre-eclampsia. CONCLUSION: The prevalence of IL-17-producing CD4, CD8 and NK cells is elevated in pre-eclampsia, indicating that both the innate and adaptive arms of the immune system are involved in the development of the exaggerated maternal systemic inflammation observed in this pregnancy-specific disorder.
机译：问题：系统性炎症是先兆子痫发病机理的主要组成部分。除了Th1和Th2细胞的失衡，Th17和调节性T细胞的患病率的改变也被认为有助于炎症。我们旨在描述先兆子痫和正常妊娠中这四种CD4淋巴细胞亚型的发生率，以及产生IL-17的CD8和NK细胞的患病率。研究方法：本研究招募了20名先兆子痫孕妇和22名正常孕妇。使用流式细胞仪，我们确定了CD4，CD8和NK细胞亚群中产生IL-17的细胞的患病率。此外，我们测量了CD4 + Tregs的患病率，并使用细胞表面趋化因子受体标记物表征了Th1 / Th2细胞。结果：我们证明，不仅子痫前期的Th1 / Th2发生变化，而且Th17 / Treg发生变化，也倾向于偏向偏向促炎状态。在子痫前期中，表达IL-17的CD8和NK细胞的比例也较高。结论：先兆子痫中产生IL-17的CD4，CD8和NK细胞的患病率升高，表明免疫系统的先天和适应性臂均参与了该妊娠中观察到的母体系统性炎症的发展。特异性疾病。

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