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首页> 外文期刊>AJRI: American Journal of Reproductive Immunology >Female genital tract secretions and semen impact the development of microbicides for the prevention of HIV and other sexually transmitted infections.
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Female genital tract secretions and semen impact the development of microbicides for the prevention of HIV and other sexually transmitted infections.

机译：女性生殖道分泌物和精液会影响杀微生物剂的发展，以预防艾滋病毒和其他性传播感染。

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摘要

Pharmacologic strategies for the prevention of HIV include vaccines, post-exposure prophylaxis with antiretroviral therapy, and topical microbicides. Vaginal microbicides have the potential to augment innate defenses in the genital tract but may also disrupt endogenous protection and increase HIV acquisition risk, as observed in clinical trials of nonoxynol-9. The initially disappointing results of microbicide clinical trials stimulated the development of more sensitive and comprehensive pre-clinical safety studies, which include dual-chamber culture systems to model the epithelial barrier and post-coital studies to evaluate the effects of semen and sexual intercourse on microbicide efficacy. This review discusses the key factors that contribute to a healthy female genital tract environment, the impact of semen on mucosal defense, and how our understanding of these mediators informs the development of effective vaginal microbicides.
机译：预防HIV的药理策略包括疫苗，抗逆转录病毒疗法的暴露后预防和局部杀菌剂。阴道杀微生物剂有可能增强生殖道的先天防御能力，但也可能破坏内源性保护作用并增加HIV感染风险，如Nonoxynol-9的临床试验所观察到的。最初令人失望的杀微生物剂临床试验结果刺激了更敏感，更全面的临床前安全性研究的发展，包括双室培养系统对上皮屏障进行建模以及性交后研究以评估精液和性交对杀微生物剂的影响功效。这篇综述讨论了有助于健康的女性生殖道环境的关键因素，精液对粘膜防御的影响以及我们对这些介体的了解如何指导有效的阴道杀菌剂的发展。

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