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首页> 外文期刊>Digestive Diseases and Sciences >Leuprolide Acetate, a GnRH Agonist, Improves the Neurogenic Bowel in Ovariectomized Rats with Spinal Cord Injury
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Leuprolide Acetate, a GnRH Agonist, Improves the Neurogenic Bowel in Ovariectomized Rats with Spinal Cord Injury

机译：醋酸甘露糖苷，一种GnRH激动剂，改善了卵巢损伤卵巢切除大鼠的神经源性肠

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Background Electromyographic studies have shown that external anal sphincter activity is modified in response to distension in animals with spinal cord injury. Gonadotropin-releasing hormone and its agonist leuprolide acetate have neurotrophic properties in animals with spinal cord injury. Aim This study was to determine the effects of leuprolide acetate treatment on electromyographic activity of the external anal sphincter and anorectal manometry in ovariectomized rats with spinal cord injury. Methods Adult ovariectomized rats were divided in three groups: (a) sham of spinal cord injury, (b) spinal cord injury treated with saline solution, and (c) spinal cord injury treated with leuprolide acetate. The spinal cord injury was induced by clamping at level T9. Leuprolide acetate dosage of 10 mu g/kg was proctored intramuscular for 5 weeks, commencing the day after the lesion. Electromyography of the external anal sphincter, anorectal manometry, and volume of the cecum were evaluated in all groups. Results The electromyographic study of the external anal sphincter activity showed a significant improvement in injured rats treated with leuprolide acetate. Manometric analysis and cecum volume data obtained in animals with leuprolide acetate were very similar to those found in the sham group. Conclusions These results demonstrate that leuprolide acetate treatment improves the neurogenic colon in ovariectomized rats with spinal cord injury.
机译：背景技术电拍摄研究表明，响应于具有脊髓损伤的动物的差异而改变外部肛门括约肌活性。促性腺激素释放激素及其激动剂乳酸醋酸乙酸酯在具有脊髓损伤的动物中具有神经营养性质。目的本研究是确定血液切除大鼠外部肛门括约肌和肛门切除测量的血纯化物体对脊髓损伤的大鼠肛门细胞测控的影响。方法将成人卵巢切除大鼠分为三组：（a）脊髓损伤的假，（b）用盐水溶液处理的脊髓损伤，并用醋酸甘油酯处理脊髓损伤。通过在T9水平钳位诱导脊髓损伤。月亮醋酸盐剂量为10μg/ kg，肌肉注射5周，开始后一天开始。在所有基团中评估外部肛门括约肌，肛门直肠测控和盲肠体积的肌电学。结果外部肛门括约肌的肌电分析研究表明，用甘醇乙酸盐处理的受伤大鼠显着改善。在具有雌丙醇酯乙酸盐中的动物中获得的测量分析和盲肠体积数据与假群中的那些非常相似。结论这些结果表明，血红蛋白治疗改善脊髓损伤的卵巢切除大鼠中的神经源性结肠。

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