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首页> 外文期刊>Drug development and industrial pharmacy >The composition of NF-defined emulsifiers: sorbitan monolaurate, monopalmitate, monostearate, monooleate, polysorbate 20, polysorbate 40, polysorbate 60, and polysorbate 80.
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The composition of NF-defined emulsifiers: sorbitan monolaurate, monopalmitate, monostearate, monooleate, polysorbate 20, polysorbate 40, polysorbate 60, and polysorbate 80.

机译:NF定义的乳化剂的组成:脱水山梨糖醇单位酸盐,单透孔,单硬脂酸酯,单烯酸酯,聚山梨醇酯20,聚山梨醇酯40,聚山梨醇酯60和聚山梨醇酯80。

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摘要

Using the analytical constants for sorbitan monolaurate, monopalmitate, monostearate, and monooleate given in the National Formulary (NF), calculations were carried out that indicated that these emulsifiers are esters of sorbitol mono- and dianhydrides. Contrary to the NF description, no significant amount of sorbitol ester was calculated to be present, in agreement with recent experimental findings. Further calculations were made using the NF-defined analytical constants of polysorbate 20, polysorbate 40, polysorbate 60, and polysorbate 80, which indicate that these emulsifiers are esters primarily of polyoxyethylated sorbitol monoanhydride (i.e., sorbitan), with lesser quantities of polyoxyethylated esters of sorbitol dianhydride. Since all hydroxyl groups of the polysorbates are primary, random distribution of acyl groups on the available hydroxyls can be assumed, and the likely composition of these emulsifiers can be calculated. The most abundant compounds appear to be polyoxyethylated sorbitan mono-, di-, and triesters. Although the polysorbates are stated to contain 20 moles of ethylene oxide per mole of ester, the oxyethylene contents stated in the Food Chemicals Codex reveal that somewhat more than 20 moles of ethylene oxide are combined.
机译:在全国性美容(NF)中给予的脱水山梨糖醇单卤酸盐的分析常数,单渗透性,单硬脂酸酯和单烯开鬼,表明这些乳化剂是山梨糖醇单和二酐的酯。与NF描述相反,与最近的实验结果一致,没有计算出现大量的山梨糖醇酯。使用聚山梨醇酯20,聚山梨醇酯40,聚山梨醇酯60和聚山梨醇酯80的NF定义的分析常数进行了进一步的计算,这表明这些乳化剂是主要是聚氧乙基化山梨糖醇单酐(即脱山梨糖醇)的酯,其数量较少量的聚氧乙基化酯山梨糖醇二酐。由于聚山梨醇酯的所有羟基是初级的,因此可以假设可用羟基上的酰基的随机分布,并且可以计算这些乳化剂的可能组成。最丰富的化合物似乎是聚氧乙基化脱水山梨糖醇单,二 - 和高潮。虽然聚冰片酯每摩尔酯含有20摩尔的环氧乙烷,但食品化学品Codex中所述的氧乙基内容物揭示了略微超过20摩尔环氧乙烷。

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