Dendrimer nanoarchitectures for cancer diagnosis and anticancer drug delivery

Sharma Ashok Kumar; Gothwal Avinash; Kesharwani Prashant; Alsaab Hashem; Iyer Arun K.; Gupta Umesh

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Dendrimer nanoarchitectures for cancer diagnosis and anticancer drug delivery

机译：Dendrimer纳米建筑癌症诊断和抗癌药物递送

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Dendrimers are novel nanoarchitectures with unique properties including a globular 3D shape, a monodispersed unimicellar nature and a nanometric size range. The availability of multiple peripheral functional groups and tunable surface engineering enable the facile modification of the dendrimer surface with different therapeutic drugs, diagnostic agents and targeting ligands. Drug encapsulation, and solubilizing and passive targeting also equally contribute to the therapeutic use of dendrimers. In this review, we highlight recent advances in the delivery of anticancer drugs using dendrimers, as well as other biomedical and diagnostic applications. Taken together, the immense potential and utility of dendrimers are envisaged to have a significant positive impact on the growing arena of drug delivery and targeting.

机译：树枝状大分子是新型纳米建筑，具有独特的性质，包括球状3D形状，单分散的unimicellar性质和纳米尺寸范围。多个外围官能团和可调谐表面工程的可用性使得树枝状体表面具有不同的治疗药物，诊断剂和靶向配体的体积改变。药物包封，溶解和无源靶向也同样有助于树枝状大分子的治疗用途。在这篇综述中，我们突出了使用树枝状体和其他生物医学和诊断应用来突出抗癌药物的最新进展。携带在一起，设想树枝状像树枝状大分子的巨大潜力和效用对药物递送和靶向的不断增长的竞技场产生显着的积极影响。

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《Drug discovery today》 |2017年第2期|共13页
作者
Sharma Ashok Kumar; Gothwal Avinash; Kesharwani Prashant; Alsaab Hashem; Iyer Arun K.; Gupta Umesh;
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作者单位

Cent Univ Rajasthan Sch Chem Sci &

Pharm Dept Pharm Ajmer 305817 Rajasthan India;

Cent Univ Rajasthan Sch Chem Sci &

Pharm Dept Pharm Ajmer 305817 Rajasthan India;

Int Med Univ Sch Pharm Dept Pharmaceut Technol Jalan Jalil Perkasa 19 Kuala Lumpur 57000;

Wayne State Univ Use Inspired Biomat &

Integrated Nano Delivery U Dept Pharmaceut Sci Eugene;

Wayne State Univ Use Inspired Biomat &

Integrated Nano Delivery U Dept Pharmaceut Sci Eugene;

Cent Univ Rajasthan Sch Chem Sci &

Pharm Dept Pharm Ajmer 305817 Rajasthan India;

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正文语种 eng
中图分类药学;
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专利

1. Dendrimer nanoarchitectures for cancer diagnosis and anticancer drug delivery [J] . Sharma Ashok Kumar, Gothwal Avinash, Kesharwani Prashant, Drug discovery today . 2017,第2期

机译：Dendrimer纳米建筑癌症诊断和抗癌药物递送
2. Dendrimers in anticancer drug delivery: mechanism of interaction of drug and dendrimers [J] . Singh Jaspreet, Jain Keerti, Mehra Neelesh Kumar, Artificial cells, nanomedicine, and biotechnology. . 2016,第5a8期

机译：树枝状大分子在抗癌药物递送中的作用：药物与树枝状大分子相互作用的机理
3. Dendrimers in anticancer drug delivery: mechanism of interaction of drug and dendrimers [J] . Jaspreet Singh, Keerti Jain, Neelesh Kumar Mehra, Artificial cells, nanomedicine, and biotechnology. . 2016,第7期

机译：树枝状大分子在抗癌药物递送中的作用：药物与树枝状大分子相互作用的机理
4. Monocytes Hybridized with PAMAM Dendrimer-Doxorubicin Conjugates for Anticancer Drug Delivery [C] . Christopher A. Holden, W. Andrew Yeudall, Hu Yang Annual meeting of the Society for Biomaterials . 2011

机译：单核细胞与PAMAM树状大分子-阿霉素的缀合物抗癌药物传递。
5. Synthesis of New Generation Taxoid Anticancer Agents and Dendrimer-Based Multifunctional Conjugates for Tumor-Targeting Drug Delivery. [D] . Sun, Yi. 2016

机译：合成新型紫杉类抗癌剂和基于树状聚合物的多功能偶联物，用于靶向肿瘤的药物递送。
6. Trastuzumab-grafted PAMAM dendrimers for the selective delivery of anticancer drugs to HER2-positive breast cancer [O] . Hitesh Kulhari, Deep Pooja, Shweta Shrivastava, -1

机译：曲妥珠单抗移植的PAMAM树状聚合物可选择性地将抗癌药物递送至HER2阳性乳腺癌
7. Combination of Dendrimer-Nanovector-Mediated Small Interfering RNA Delivery to Target Akt with the Clinical Anticancer Drug Paclitaxel for Effective and Potent Anticancer Activity in Treating Ovarian Cancer [O] . Shashwati Kala, Abby Sin Chi Mak, Xiaoxuan Liu, 2014

机译：树枝状大分子-纳米载体介导的小分子干扰RNA传递至靶点Akt与临床抗癌药紫杉醇联合用于有效有效治疗卵巢癌的有效抗癌活性

Dendrimer nanoarchitectures for cancer diagnosis and anticancer drug delivery

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