New concepts in asthma: clinical phenotypes and pathophysiological mechanisms

Koczulla Andreas R.; Vogelmeier Claus F.; Garn Holger; Renz Harald

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New concepts in asthma: clinical phenotypes and pathophysiological mechanisms

机译：哮喘的新概念：临床表型和病理生理机制

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Asthma is among the most common chronic inflammatory diseases worldwide. Recent evidence indicates that the pathogenesis shows a high degree of heterogeneity. Patient subsets have been identified that exhibit different cellular and molecular patterns of dysregulation. A prominent example is eosinophilic Th2-driven asthma. These unique and molecular patterns are termed endotypes. Characterization of endotypes has broad implications for therapeutic interventions. Although similar to 80% of asthmatic patients respond well to standard anti-inflammatory therapies, the remaining subset particularly consisting of severe patients requires a more specialized endotype-specific approach. This interrelationship between clinical phenotypes, molecular endotypes and endotype-specific therapies is the focus of this review.

机译：哮喘是全球最常见的慢性炎症性疾病之一。最近的证据表明发病机制显示出高度的异质性。已经鉴定了患者子集，其表现出不同的细胞和分子模式的失调。一个突出的例子是嗜酸性粒细胞的哮喘。这些独特和分子模式称为内型。内克内斯的表征对治疗干预具有广泛的影响。虽然类似于80％的哮喘患者对标准的抗炎疗法响应良好，但剩余的亚特色特别组成的严重患者需要更专业的子型特异性方法。临床表型，分子内型和子型特异性疗法之间的这种相互关系是本综述的重点。

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《Drug discovery today》 |2017年第2期|共9页
作者
Koczulla Andreas R.; Vogelmeier Claus F.; Garn Holger; Renz Harald;
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作者单位

Philipps Univ Marburg Dept Med Pulm &

Crit Care Med Univ Med Ctr Giessen &

Marburg Baldingerstr;

Philipps Univ Marburg Dept Med Pulm &

Crit Care Med Univ Med Ctr Giessen &

Marburg Baldingerstr;

Philipps Univ Marburg Inst Lab Med &

Pathobiochem Fac Med Mol Diagnost Baldingerstr D-35043;

Philipps Univ Marburg Inst Lab Med &

Pathobiochem Fac Med Mol Diagnost Baldingerstr D-35043;

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原文格式 PDF
正文语种 eng
中图分类药学;
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1. New concepts in asthma: clinical phenotypes and pathophysiological mechanisms [J] . Koczulla Andreas R., Vogelmeier Claus F., Garn Holger, Drug discovery today . 2017,第2期

机译：哮喘的新概念：临床表型和病理生理机制
2. Clinical phenotypes of asthma should link up with disease mechanisms [J] . Chung Kian Fan, Adcock Ian M. Current opinion in allergy and clinical immunology . 2015,第Pta1期

机译：哮喘的临床表型应与疾病机制联系起来
3. How Variability in Clinical Phenotypes Should Guide Research into Disease Mechanisms in Asthma [J] . Kian Fan Chung, Ian M. Adcock Annals of the American Thoracic Society . 2014,第Suppla期

机译：临床表型的变异性应如何指导哮喘的发病机制研究
4. Clinical Phenotypes of Asthma [C] . Tzortzaki Eleni, Siafakas Nikolaos World Congress of Asthma . 2011

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5. AN IN-DEPTH STUDY OF 'CURLING'S ULCER' WITH SPECIAL REFERENCE TO THE CONCEPT OF THE SEVERE BURN AS A TOTAL BODY INJURY AND A CLINICAL AND EXPERIMENTAL INVESTIGATION OF SOME PATHOPHYSIOLOGIC FEATURES OF POST BURNGASTROINTESTINAL ULCERATION. [D] . DAY, STACEY BISWAS. 1971

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6. How Variability in Clinical Phenotypes Should Guide Research into Disease Mechanisms in Asthma [O] . Kian Fan Chung, Ian M. Adcock -1

机译：临床表型的变异性应如何指导哮喘的发病机制研究
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机译：心脏重塑：概念，临床影响，病理生理机制和药物治疗

New concepts in asthma: clinical phenotypes and pathophysiological mechanisms

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