Pharmacogenomics of the cytochrome P450 2C family: impacts of amino acid variations on drug metabolism

Isvoran Adriana; Louet Maxime; Vladoiu Diana Larisa; Craciun Dana; Loriot Marie-Anne; Villoutreix Bruno O.; Miteva Maria A.

首页> 外文期刊>Drug discovery today >Pharmacogenomics of the cytochrome P450 2C family: impacts of amino acid variations on drug metabolism

【24h】

Pharmacogenomics of the cytochrome P450 2C family: impacts of amino acid variations on drug metabolism

机译：细胞色素P450 2C系列的药物替补：氨基酸变异对药物代谢的影响

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Pharmacogenomics investigates DNA and RNA variations in the human genome related to drug responses. Cytochrome P450 (CYP) is a supergene family of drug-metabolizing enzymes responsible for the metabolism of approximately 90% of human drugs. Among the major CYP isoforms, the CYP2C subfamily is of clinical significance because it metabolizes approximately 20% of clinically administrated drugs and represents several variant alleles leading to adverse drug reactions or altering drug efficacy. Here, we review recent progress on understanding the interindividual variability of the CYP2C members and the functional and clinical impact on drug metabolism. We summarize current advances in the molecular modeling of CYP2C polymorphisms and discuss the structural bases and molecular mechanisms of amino acid variants of CYP2C members that affect drug metabolism.

机译：药癌组学研究了与药物反应有关的人类基因组的DNA和RNA变化。细胞色素P450（CYP）是一种超级基础类药物代谢酶，其负责约90％的人类药物的代谢。在主要CYP同种型中，CYP2C亚家族具有临床意义，因为它代谢了大约20％的临床施用药物，并且代表了几个变异等位基因，导致药物不良反应或改变药物功效。在这里，我们审查了最近了解CYP2C成员的联系变异性以及对药物代谢的功能和临床影响的进展。我们总结了CYP2C多态性的分子模拟中的电流进展，并讨论了影响药物代谢的CYP2C成员氨基酸变体的结构基础和分子机制。

著录项

来源
《Drug discovery today》 |2017年第2期|共11页
作者
Isvoran Adriana; Louet Maxime; Vladoiu Diana Larisa; Craciun Dana; Loriot Marie-Anne; Villoutreix Bruno O.; Miteva Maria A.;
展开▼
作者单位

West Univ Timisoara Dept Biol &

Chem 16 Pestalozzi Timisoara 300115 Romania;

Univ Paris Diderot Sorbonne Paris Cite Inserm UMR S 973 Mol Therapeut In Sil 39 Rue Helene;

West Univ Timisoara Dept Biol &

Chem 16 Pestalozzi Timisoara 300115 Romania;

West Univ Timisoara Teacher Training Dept Blvd V Parvan Timisoara 300223 Romania;

Ctr Univ St Peres INSERM UMR S1147 45 Rue St Peres F-75006 Paris France;

Univ Paris Diderot Sorbonne Paris Cite Inserm UMR S 973 Mol Therapeut In Sil 39 Rue Helene;

Univ Paris Diderot Sorbonne Paris Cite Inserm UMR S 973 Mol Therapeut In Sil 39 Rue Helene;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;
关键词

相似文献

外文文献
中文文献
专利

1. Pharmacogenomics of the cytochrome P450 2C family: impacts of amino acid variations on drug metabolism [J] . Isvoran Adriana, Louet Maxime, Vladoiu Diana Larisa, Drug discovery today . 2017,第2期

机译：细胞色素P450 2C系列的药物替补：氨基酸变异对药物代谢的影响
2. Pharmacogenomics of poor drug metabolism in Greyhounds: Cytochrome P450 (CYP) 2B11 genetic variation, breed distribution, and functional characterization [J] . Stephanie E. Martinez, Marie C. Andresen, Zhaohui Zhu, Scientific reports. . 2020,第1期

机译：灰狗药物代谢差的药物替补：细胞色素P450（CYP）2B11遗传变异，品种分布和功能性格
3. Drug-drug interactions in the metabolism of imidafenacin: role of the human cytochrome P450 enzymes and UDP-glucuronic acid transferases, and potential of imidafenacin to inhibit human cytochrome P450 enzymes. [J] . Kanayama N, Kanari C, Masuda Y, Xenobiotica: the fate of foreign compounds in biological systems . 2007,第2期

机译：吡虫啉新陈代谢中的药物相互作用：人类细胞色素P450酶和UDP-葡萄糖醛酸转移酶的作用，以及吡虫啉抑制人细胞色素P450酶的潜力。
4. Influence of amino acid residues near the active site of cytochrome P450 from Bacillus megaterium on the selectivity of n-octane oxidation to octanol regioisomers [C] . Akimitsu Miyaji, Toshihide Baba International Conference on Chemical Engineering, Food and Biotechnology . 2017

机译：芽孢杆菌P450活性位点附近氨基酸残基与芽孢杆菌氧化对辛醇再氧化对辛醇再生体的选择性的影响
5. Phytochemical variation in Canadian Hydrastis canadensis L. (goldenseal) and the in vitro inhibition of human cytochrome P450-mediated drug metabolism by H. canadensis and other botanicals. [D] . Leduc, Renee Irene. 2007

机译：加拿大Hydrastis canadensis L.（goldenseal）的植物化学变化以及加拿大H. canadensis和其他植物药对人细胞色素P450介导的药物代谢的体外抑制。
6. Determination of Cytochrome P450 Isoenzyme 2D6 (CYP2D6) Genotypes and Pharmacogenomic Impact on Primaquine Metabolism in an Active-Duty US Military Population [O] . Michele D Spring, Jason C Sousa, Qigui Li, -1

机译：在美国现役军人中细胞色素P450同工酶2D6（CYP2D6）基因型的确定及其药物基因组学对伯氨喹代谢的影响
7. ISOFORM(S) OF CYTOCHROME P450 RESPONSIBLE FOR THE METABOLISM OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS: OXIDATIVE METABOLISM OF MEFENAMIC ACID AND DICLOFENAC BY CYP2C SUBFAMILY [O] . Kan CHIBA, Atuko SAITOH, Tomie CHIBA, 1994

机译：同种型细胞色素p450负责非甾体类抗炎药的代谢：Cyp2c亚家族的梅芬酸和双氯芬酸的氧化代谢

Pharmacogenomics of the cytochrome P450 2C family: impacts of amino acid variations on drug metabolism

摘要

著录项

相似文献

相关主题

期刊订阅