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首页> 外文期刊>Alcohol >Alcohol consumption and lipodystrophy in HIV-infected adults with alcohol problems.
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Alcohol consumption and lipodystrophy in HIV-infected adults with alcohol problems.

机译：在患有酒精问题的HIV感染成年人中，饮酒和脂肪营养不良。

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Lipodystrophy is a common long-term complication of HIV infection that may lead to decreased quality of life and less adherence to antiretroviral therapy (ART). A complete understanding of the etiology of HIV-associated lipodystrophy has not yet been achieved, although factors related to the virus, per se, and use of ART appear to be related. Alcohol use is common among HIV-infected patients and has biological effects on fat distribution, yet alcohol's relationship to HIV-associated lipodystrophy has not been examined. The goal of this clinical study was to assess the effect of alcohol consumption on lipodystrophy in HIV-infected adults with alcohol problems. This was a prospective study (2001-2006) of 289 HIV-infected persons with alcohol problems. The primary outcome was self-reported lipodystrophy, which was assessed at one time point (median 29 months after enrollment). Alcohol use was assessed every 6 months and classified as: abstinent at all interviews; > or = 1 report of moderate drinking but no heavy drinking; 1 or 2 reports of heavy drinking; or > or = 3 reports of heavy drinking. Multivariable logistic regression models were fit to the data. Fifty-two percent (150/289) of subjects reported lipodystrophy. Alcohol consumption was: 34% abstinent at all interviews; 12% > or = 1 report of moderate drinking, but no heavy drinking; 34% 1-2 reports of heavy drinking; and 20% > or = 3 reports of heavy drinking. Although not statistically significant, subjects with alcohol use had a higher odds of lipodystrophy (adjusted odds ratios and 95% confidence interval: > or = 1 report of moderate drinking, 2.36 [0.89, 6.24]; 1-2 reports of heavy drinking, 1.34 [0.69, 2.60]; > or = 3 reports of heavy drinking, 2.07 [0.90, 4.73]). Alcohol use may increase the odds of developing HIV-associated lipodystrophy among subjects with alcohol problems. However, larger studies are needed to fully elucidate the role and impact of alcohol consumption on the development of this common long-term complication of HIV infection and its treatment.
机译：脂肪营养不良是艾滋病毒感染的常见长期并发症，可能导致生活质量下降和对抗逆转录病毒疗法（ART）的依从性降低。尽管与病毒本身相关的因素和抗病毒治疗的使用似乎相关，但尚未完全了解与HIV相关的脂肪营养不良的病因。饮酒在感染HIV的患者中很常见，并且对脂肪分布具有生物学影响，但是酒精与HIV相关的脂肪营养不良之间的关系尚未得到检验。这项临床研究的目的是评估饮酒对患有酒精问题的HIV感染成年人的脂肪营养不良的影响。这项前瞻性研究（2001年至2006年）是对289名患有酒精问题的HIV感染者的一项前瞻性研究。主要结局是自我报告的脂肪营养不良，在一个时间点（入组后29个月中位数）进行评估。每6个月评估一次饮酒情况，并将其分类为：所有访谈中都戒酒; >或= 1次中度饮酒但不大量饮酒的报告; 1或2次大量饮酒的报道;或>或= 3次酗酒报告。多变量逻辑回归模型适合数据。 52％（150/289）的受试者报告了脂肪营养不良。饮酒：在所有访谈中戒酒率为34％; 12％>或= 1次中度饮酒，但不大量饮酒的报告; 34％1-2报告大量饮酒;和20％>或= 3次大量饮酒的报告。尽管无统计学意义，但饮酒的受试者脂肪营养不良的几率更高（调整后的几率和95％置信区间：>或= 1例中度饮酒，2.36 [0.89，6.24]; 1-2例中度饮酒，1.34 [0.69，2.60];>或= 3次大量饮酒的报告，2.07 [0.90，4.73]。在有酒精问题的受试者中，饮酒可能会增加与HIV相关的脂肪营养不良的可能性。但是，需要进行更大的研究才能充分阐明饮酒对这种常见的HIV感染长期并发症及其治疗发展的作用和影响。

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